ArticleProceedings of the National Academy of Sciences of the United States of America2001
Genomic analysis of orthologous mouse and human olfactory receptor loci.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 98 citations in OpenAlex.
- Roles of sensory receptors in non-sensory organs: the kidney and beyond.Nature reviews. Nephrology · 2025Review
- Bioinformatics Discovery of Putative Enhancers within Mouse Odorant Receptor Gene Clusters.Chemical senses · 2019Article
- A purely bioinformatic pipeline for the prediction of mammalian odorant receptor gene enhancers.BMC bioinformatics · 2019Article
- Alternative polyadenylation produces multiple 3' untranslated regions of odorant receptor mRNAs in mouse olfactory sensory neurons.BMC genomics · 2019Article
- Regulatory Features for Odorant Receptor Genes in the Mouse Genome.Frontiers in genetics · 2017Review
- The Mouse Solitary Odorant Receptor Gene Promoters as Models for the Study of Odorant Receptor Gene Choice.PloS one · 2016Article
- Identification of novel post-transcriptional features in olfactory receptor family mRNAs.Nucleic acids research · 2015Article
- Nuclear compartmentalization of odorant receptor genes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation.PLoS biology · 2013Article
- Promoter architecture of mouse olfactory receptor genes.Genome research · 2012Article
- Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifs.BMC genomics · 2011Article
- Homeodomain binding motifs modulate the probability of odorant receptor gene choice in transgenic mice.Molecular and cellular neurosciences · 2011Article
- Asymmetric and non-uniform evolution of recently duplicated human genes.Biology direct · 2010Article
- Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species.Immunogenetics · 2010Review
- Achieving singularity in mammalian odorant receptor gene choice.Chemical senses · 2010Review
- Evolution of transcription factor binding sites in mammalian gene regulatory regions: handling counterintuitive results.Journal of molecular evolution · 2009Article
- Article
- Mammalian olfactory receptors.Frontiers in cellular neuroscience · 2009Article
- Genome-wide patterns of gene flow across a house mouse hybrid zone.Genome research · 2008Article
- Co-regulation of a large and rapidly evolving repertoire of odorant receptor genes.BMC neuroscience · 2007Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Olfactory receptor (OR) genes represent approximately 1% of genomic coding sequence in mammals, and these genes are clustered on multiple chromosomes in both the mouse and human genomes. We have taken a comparative genomics approach to identify features that may be involved in the dynamic evolution of this gene family and in the transcriptional control that results in a single OR gene expressed per olfactory neuron. We sequenced approximately 350 kb of the murine P2 OR cluster and used synteny, gene linkage, and phylogenetic analysis to identify and sequence approximately 111 kb of an orthologous cluster in the human genome. In total, 18 mouse and 8 human OR genes were identified, including 7 orthologs that appear to be functional in both species. Noncoding homology is evident between orthologs and generally is confined within the transcriptional unit. We find no evidence for common regulatory features shared among paralogs, and promoter regions generally do not contain strong promoter motifs. We discuss these observations, as well as OR clustering, in the context of evolutionary expansion and transcriptional regulation of OR repertoires.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.