ArticleProceedings of the National Academy of Sciences of the United States of America2001
Vasopressin mRNA localization in nerve cells: characterization of cis-acting elements and trans-acting factors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 38 citations in OpenAlex.
- Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons.The Journal of cell biology · 2014Article
- Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification.Biology open · 2012Article
- Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells.The Journal of biological chemistry · 2012Article
- Conservation of the RNA Transport Machineries and Their Coupling to Translation Control across Eukaryotes.Comparative and functional genomics · 2012Article
- Axonal Localization of transgene mRNA in mature PNS and CNS neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Spatial code recognition in neuronal RNA targeting: role of RNA-hnRNP A2 interactions.The Journal of cell biology · 2011Article
- Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain.PloS one · 2010Article
- Article
- K-turn motifs in spatial RNA coding.RNA biology · 2006Review
- Interaction of paxillin with poly(A)-binding protein 1 and its role in focal adhesion turnover and cell migration.Molecular and cellular biology · 2005Article
- Presence of a poly(A) binding protein and two proteins with cell cycle-dependent phosphorylation in Crithidia fasciculata mRNA cycling sequence binding protein II.Eukaryotic cell · 2004Article
- Candidate RNA-binding proteins regulating extrasomatic mRNA targeting and translation in mammalian neurons.Molecular neurobiology · 2002Review
- Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
mRNA localization is a complex pathway. Besides mRNA sorting per se, this process includes aspects of regulated translation. It requires protein factors that interact with defined sequences (or sequence motifs) of the transcript, and the protein/RNA complexes are finally guided along the cytoskeleton to their ultimate destinations. The mRNA encoding the vasopressin (VP) precursor protein is localized to the nerve cell processes in vivo and in primary cultured nerve cells. Sorting of VP transcripts to dendrites is mediated by the last 395 nucleotides of the mRNA, the dendritic localizer sequence, and it depends on intact microtubules. In vitro interaction studies with cytosolic extracts demonstrated specific binding of a protein, enriched in nerve cell tissues, to the radiolabeled dendritic localizer sequence probe. Biochemical purification revealed that this protein is the multifunctional poly(A)-binding protein (PABP). It is well known for its ability to bind with high affinity to poly(A) tails of mRNAs, prerequisite for mRNA stabilization and stimulation of translational initiation, respectively. With lower affinities, PABP can also associate with non-poly(A) sequences. The physiological consequences of these PABP/RNA interactions are far from clear but may include functions such as translational silencing. Presumably, the translational state of mRNAs subject to dendritic sorting is influenced by external stimuli. PABP thus could be a component required to regulate local synthesis of the VP precursor and possibly of other proteins.
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