ArticleMolecular and cellular biology2001
Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 103 citations in OpenAlex.
- TLE4 is a repressor of the oncogenic activity of TLX3 in T-cell acute lymphoblastic leukemia.Leukemia · 2025Article
- Roles of transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation.Frontiers in cell and developmental biology · 2022Review
- WD Repeat Domain 77 Protein Regulates Translation of E2F1 and E2F3 mRNA.Molecular and cellular biology · 2020Article
- The function of tcf3 in medaka embryos: efficient knockdown with pePNAs.BMC biotechnology · 2018Article
- Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.Cancer science · 2017Article
- Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Review
- cGMP-dependent protein kinase Iβ interacts with p44/WDR77 to regulate androgen receptor-driven gene expression.PloS one · 2014Article
- Androgen receptor epigenetics.Translational andrology and urology · 2013Article
- Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development.Molecular endocrinology (Baltimore, Md.) · 2013Article
- PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation.The Journal of biological chemistry · 2013Article
- GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos.PloS one · 2013Article
- Loss of the androgen receptor cofactor p44/WDR77 induces astrogliosis.Molecular and cellular biology · 2012Article
- TFIIH is an elongation factor of RNA polymerase I.Nucleic acids research · 2012Article
- Androgen receptor repression of GnRH gene transcription.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.The Journal of biological chemistry · 2011Article
- Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.The Journal of biological chemistry · 2011Article
- Nuclear transport signals control cellular localization and function of androgen receptor cofactor p44/WDR77.PloS one · 2011Article
- AES/GRG5: more than just a dominant-negative TLE/GRG family member.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A yeast two-hybrid assay has identified an androgen-dependent interaction of androgen receptor (AR) with amino-terminal enhancer of split (AES), a member of the highly conserved Groucho/TLE family of corepressors. Full-length AR, as well as the N-terminal fragment of AR, showed direct interactions with AES in in vitro protein-protein interaction assays. AES specifically inhibited AR-mediated transcription in a well-defined cell-free transcription system and interacted specifically with the basal transcription factor (TFIIE) in HeLa nuclear extract. These observations implicate AES as a selective repressor of ligand-dependent AR-mediated transcription that acts by directly interacting with AR and by targeting the basal transcription machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.