ArticleEMBO reports2001
Thyroid hormone regulates the obesity gene tub.
Article in EMBO reports, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- TUB gene expression in hypothalamus and adipose tissue and its association with obesity in humans.International journal of obesity (2005) · 2018Pooled it
- miR-10b-5p regulates adipocyte lineage commitment and adipogenesis via targeting of Gata6 and Tubby.Cell communication and signaling : CCS · 2026Article
- Acute exercise reduces feeding by activating IL-6/Tubby axis in the mouse hypothalamus.Frontiers in physiology · 2022Article
- Candidate variants in TUB are associated with familial tremor.PLoS genetics · 2020Article
- Promoting Effect of L-tyrosine Supplement on New Zealand Rabbit Bucks' Performance and Reproduction Through Upregulation of Steroidogenic Markers.Frontiers in veterinary science · 2020Article
- Impact of Obesity on Serum Levels of Thyroid Hormones among Euthyroid Saudi Adults.Journal of thyroid research · 2017Article
- Insulin Phosphorylates Tyrosine Residue 464 of Tub and Translocates Tubby into the Nucleus in HIRcB Cells.Endocrinology and metabolism (Seoul, Korea) · 2014Article
- Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei.Diabetes · 2013Article
- The effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Unconventional secretion of tubby and tubby-like protein 1.FEBS letters · 2009Article
- Microarray analysis of differentially expressed genes in the brains of tubby mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2009Article
- DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Reduced activity without hyperphagia contributes to obesity in Tubby mutant mice.Physiology & behavior · 2008Article
- Thyroid dysfunction and their relation to cardiovascular risk factors such as lipid profile, hsCRP, and waist hip ratio in Korea.The Korean journal of internal medicine · 2003Article
- Thyroid hormones before and after weight loss in obesity.Archives of disease in childhood · 2002Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone T3/T4 is a major regulator of energy metabolism in vertebrates, and defects in thyroid status are frequently associated with changes in body weight. It is demonstrated here that thyroid hormone regulates in vivo and in vitro the tub gene, which when mutated in tubby mice causes obesity, insulin resistance and sensory deficits. Hypothyroidism in rats altered tub mRNA and protein in discrete brain areas. These changes could be attributed to thyroid hormone deficiency since T3/T4 treatment restored normal tub expression. T3 also upregulated tub mRNA within 4-6 h in neuronal cells in culture, suggesting that T3 is a positive regulator of tub gene expression. Thus, these results establish a novel pathway of T3 action and provide an important molecular link between thyroid status and the tubby-associated syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.