ArticleThe Biochemical journal2001
Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 1 of them a synthesis that pooled it.
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Who cites it
145 citing papers in PubMed, 1 synthesis or guideline pooled it, 470 citations in OpenAlex.
- Evolution of insecticide resistance and its mechanisms in Anopheles stephensi in the WHO Eastern Mediterranean Region.Malaria journal · 2020Pooled it
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- Pyrethroids resistance and distribution of kdr mutations (L1014F and N1575Y) in Anopheles gambiae s.l. along the south-north transect of Benin.Malaria journal · 2026Article
- Mechanism of metabolic resistance in Anopheles coluzzii to insecticides in two urban areas of southern Benin.Malaria journal · 2025Article
- Genomic Evolution and Patterns of Horizontal Gene Transfer in Coccomorpha Species.Ecology and evolution · 2025Article
- Redox metabolic disruptions in the honey bee brain following acute exposure to the pyrethroid deltamethrin.Scientific reports · 2025Article
- Transgenerational effects of peppermint essential oil on life table parameters and antioxidant enzymes in Callosobruchus maculatus.Scientific reports · 2025Article
- Oviposition Deterrence and Larvicidal Activity of Propyl Ether Dillapiole and Piperidyl Dillapiole AgainstToxics · 2025Article
- Occurrence of a population of the root-knot nematode, Meloidogyne incognita, with low sensitivity to two major nematicides, fosthiazate and fluopyram, in Japan.Pest management science · 2025Article
- Impact of Beneficial Microorganisms Inoculated Cotton Plants on Spodoptera exigua (Lepidoptera: Noctuidae).Neotropical entomology · 2024Article
- Function Analysis of Heme Peroxidase Genes, MpPxd2 and MpPxd4, Under Thiacloprid Exposure in the Neonicotinoid-ResistantAntioxidants (Basel, Switzerland) · 2024Article
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- Whole transcriptomic analysis reveals overexpression of salivary gland and cuticular proteins genes in insecticide-resistant Anopheles arabiensis from Western Kenya.BMC genomics · 2024Article
- Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles.PLoS pathogens · 2023Article
- Bio-efficacy of aluminum phosphide and cypermethrin against some physiological and biochemical aspects of Chrysomya megacephala maggots.Scientific reports · 2023Article
- Impact of caffeic acid on growth, development and biochemical physiology of insect pest,Heliyon · 2023Article
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- Resistance to Beta-cypermethrin, Azadirachtin, and Matrine, and Biochemical Characterization of Field Populations of Oedaleus asiaticus (Bey-Bienko) in Inner Mongolia, Northern China.Journal of insect science (Online) · 2022Article
- Tandem duplication of a genomic region encoding glutathione S-transferase epsilon-2 and -4 genes in DDT-resistant Anopheles stephensi strain from India.Scientific reports · 2022Article
85 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selection of a laboratory colony of the brown planthopper Nilaparvata lugens with the pyrethroids permethrin and lambda-cyhalothrin increased its resistance to both insecticides. Biochemical analysis and synergistic studies with metabolic inhibitors indicated that elevated glutathione S-transferases (GSTs) with a predominant peroxidase activity conferred resistance to both pyrethroids, whereas esterases conferred part of the resistance to permethrin. Purified esterases hydrolysed permethrin at a slow rate, but incubation of either pyrethroid or their primary metabolites with partially purified GSTs had no effect on the metabolic profile. Although GSTs were sensitive to inhibition by both pyrethroids, they did not serve as binding proteins, as previously hypothesized [Grant and Matsumura (1988) Insect Biochem. 18, 615-622]. We demonstrate that pyrethroids, in addition to their neurotoxic effect, induce oxidative stress and lipid peroxidation in insects. Pyrethroid exposure induced lipid peroxides, protein oxidation and depleted reduced glutathione. Elevated GSTs in the resistant strains attenuated the pyrethroid-induced lipid peroxidation and reduced mortality, whereas their in vivo inhibition eliminated their protective role. We therefore hypothesize that the main role of elevated GSTs in conferring resistance in N. lugens is through protecting tissues from oxidative damage. Our study extends the GSTs' range of efficacy to pyrethroid insecticides and possibly explains the role of elevated GSTs in other pyrethroid-resistant insects.
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