ReviewBrain pathology (Zurich, Switzerland)2001
The role of hormones, growth factors and their receptors in pituitary tumorigenesis.
Review in Brain pathology (Zurich, Switzerland), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Extracellular signalling regulates gastrin transcription through site-specific phosphorylation and nuclear redistribution of Menin.bioRxiv : the preprint server for biology · 2026Article
- Insights into brain tumor diagnosis: exploringFrontiers in neurology · 2024Review
- Regulation of FGF2-induced proliferation by inhibitory GPCR in normal pituitary cells.Frontiers in endocrinology · 2023Article
- The microenvironment of pituitary adenomas: biological, clinical and therapeutical implications.Pituitary · 2022Review
- Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord.Journal of neuroendocrinology · 2016Review
- Pituitary adenomas: historical perspective, surgical management and future directions.CNS oncology · 2015Review
- Angiogenesis in pituitary adenomas: human studies and new mutant mouse models.International journal of endocrinology · 2014Review
- Concurrent somatotroph and plurihormonal pituitary adenomas in a cat.Journal of feline medicine and surgery · 2013Article
- Expression of cell growth negative regulators MEG3 and GADD45γ is lost in most sporadic human pituitary adenomas.Pituitary · 2012Article
- The Local Control of the Pituitary by Activin Signaling and Modulation.Open neuroendocrinology journal (Online) · 2011Article
- Determination of cell proliferation using Mcm2 antigen and evaluation of apoptosis and TGF-beta1 expression in GH-secreting or clinically nonfunctioning pituitary adenomas.Endocrine pathology · 2010Article
- Estrogen receptor-alpha mediates the epidermal growth factor-stimulated prolactin expression and release in lactotrophs.Endocrinology · 2009Article
- Treatment of gastrointestinal neuroendocrine tumors with inhibitors of growth factor receptors and their signaling pathways: recent advances and future perspectives.World journal of gastroenterology · 2008Review
- Paracrinicity: the story of 30 years of cellular pituitary crosstalk.Journal of neuroendocrinology · 2008Review
- Prolactin-releasing Peptide (PrRP) increases prolactin responses to TRH in vitro and in vivo.Endocrine · 2007Article
- PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes.Molecular cancer · 2007Article
- Gene therapy for pituitary tumors.Current gene therapy · 2005Review
- Genetics and proteomics of pituitary tumors.Endocrine · 2005Review
- Subcellular localisation of VEGF in different pituitary cells. Changes of its expression in oestrogen induced prolactinomas.Journal of molecular histology · 2005Article
- Pituitary adenomas in childhood.Indian journal of pediatrics · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous factors have been shown to govern adenohypophysial cell proliferation. Human and animal models have documented that the hypothalamic trophic hormone growth hormone-releasing hormone stimulates cell proliferation, and prolonged stimulation leads to tumor formation. Similarly, lack of dopaminergic inhibition of lactotrophs and lack of feedback suppression by adrenal, gonadal or thyroid hormones are implicated, perhaps through hypothalamic stimulatory mechanisms, in pituitary adenoma formation superimposed on hyperplasia. However, most pituitary tumors are not associated with underlying hyperplasia. Overexpression of growth factors and their receptors, such as EGF, TGFalpha, EGF-R and VEGF has been identified in pituitary adenomas, and reduction of follistatin expression has been implicated in gonadotroph adenomas. Aberrant expression of members of the FGF family, an FGF antisense gene and FGF receptors have all been described in pituitary adenomas. The clonal composition of pituitary adenomas attests to the molecular basis of pituitary tumorigenesis, however, the evidence suggests that these various hypophysiotropic hormones and growth factors likely play a role as promoters of tumor cell growth in genetically transformed cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.