ReviewMolecular neurobiology
Synaptic vesicle endocytosis: calcium works overtime in the nerve terminal.
Review in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Review
- Differential regulation of synaptic AP-2/clathrin vesicle uncoating in synaptic plasticity.Scientific reports · 2017Article
- Selective regulation of clathrin-mediated epidermal growth factor receptor signaling and endocytosis by phospholipase C and calcium.Molecular biology of the cell · 2017Article
- A Shift from a Pivotal to Supporting Role for the Growth-Associated Protein (GAP-43) in the Coordination of Axonal Structural and Functional Plasticity.Frontiers in cellular neuroscience · 2017Review
- Calcium: The Missing Link in Auxin Action.Plants (Basel, Switzerland) · 2013Review
- Tetanus toxin and botulinum toxin a utilize unique mechanisms to enter neurons of the central nervous system.Infection and immunity · 2012Article
- Activity-dependent modulation of endocytosis by calmodulin at a large central synapse.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- TGF-beta upregulation drives tertiary lymphoid organ formation and kidney dysfunction in calcineurin A-alpha heterozygous mice.American journal of physiology. Renal physiology · 2009Article
- Activity-dependent control of slow synaptic vesicle endocytosis by cyclin-dependent kinase 5.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Ever-expanding network of dynamin-interacting proteins.Molecular neurobiology · 2006Review
- Tyrosine phosphorylation of synaptophysin in synaptic vesicle recycling.Biochemical Society transactions · 2005Review
- Developmental change in the calcium sensor for synaptic vesicle endocytosis in central nerve terminals.Journal of neurochemistry · 2005Article
- Small-cell lung cancer (human): potentiation of endocytic membrane activity by voltage-gated Na(+) channel expression in vitro.The Journal of membrane biology · 2005Article
- Dynamin I phosphorylation and the control of synaptic vesicle endocytosis.Biochemical Society symposium · 2005Review
- Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functions of Ca2+ are many and varied within cells, but in the nerve terminals of neurons it has had a very defined role. That is, the influx of extracellular Ca2+ through voltage-dependent Ca2+ channels stimulates neurotransmitter release by exocytosis. For years this was assumed to be the main role for Ca2+ in this specialized subcellular region. However recent studies have shown that Ca2+ also has multiple roles in synaptic-vesicle endocytosis. This review will present evidence for three Ca2+-dependent and -independent steps; a high-affinity Ca2+-dependent triggering step, a Ca2+-independent maintenance phase, and a low-affinity Ca2+-dependent inhibition step. How the control of endocytosis by Ca2+ might impact on different neuronal functions such as synaptic transmission, the nucleation of SV endocytosis, and the repair of damaged membrane is then discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.