ArticleJournal of virology2001
Products of US22 genes M140 and M141 confer efficient replication of murine cytomegalovirus in macrophages and spleen.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Breaking barriers: how cytomegaloviruses manipulate myeloid cells to invade tissues.EMBO reports · 2026Review
- Characterization of M116.1p, a Murine Cytomegalovirus Protein Required for Efficient Infection of Mononuclear Phagocytes.Journal of virology · 2022Article
- Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication.PLoS pathogens · 2020Article
- Cytomegaloviruses and Macrophages-Friends and Foes From Early on?Frontiers in immunology · 2020Review
- SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis.Frontiers in immunology · 2019Review
- Article
- The M33 G protein-coupled receptor encoded by murine cytomegalovirus is dispensable for hematogenous dissemination but is required for growth within the salivary gland.Journal of virology · 2014Article
- Ubiquitin-independent proteasomal degradation during oncogenic viral infections.Biochimica et biophysica acta · 2011Review
- Identification and sequencing of a novel rodent gammaherpesvirus that establishes acute and latent infection in laboratory mice.Journal of virology · 2011Article
- Murine cytomegalovirus US22 protein pM140 protects its binding partner, pM141, from proteasome-dependent but ubiquitin-independent degradation.Journal of virology · 2010Article
- Murine cytomegalovirus capsid assembly is dependent on US22 family gene M140 in infected macrophages.Journal of virology · 2009Article
- Murine cytomegalovirus m142 and m143 are both required to block protein kinase R-mediated shutdown of protein synthesis.Journal of virology · 2006Article
- Human cytomegalovirus pUS24 is a virion protein that functions very early in the replication cycle.Journal of virology · 2006Article
- Mouse cytomegalovirus crosses the species barrier with help from a few human cytomegalovirus proteins.Journal of virology · 2006Article
- Experimental confirmation of global murine cytomegalovirus open reading frames by transcriptional detection and partial characterization of newly described gene products.Journal of virology · 2006Article
- Human cytomegalovirus UL130 protein promotes endothelial cell infection through a producer cell modification of the virion.Journal of virology · 2005Article
- Complex formation among murine cytomegalovirus US22 proteins encoded by genes M139, M140, and M141.Journal of virology · 2005Article
- Herpesviral Fcgamma receptors: culprits attenuating antiviral IgG?International immunopharmacology · 2004Article
- The ribonucleotide reductase R1 homolog of murine cytomegalovirus is not a functional enzyme subunit but is required for pathogenesis.Journal of virology · 2004Article
- Detection of a gene cluster that is dispensable for human herpesvirus 6 replication and latency.Journal of virology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Efficient replication of murine cytomegalovirus (MCMV) in macrophages is a prerequisite for optimal growth and spread of the virus in its natural host. Simultaneous deletion of US22 gene family members M139, M140, and M141 results in impaired replication of MCMV in macrophages and mice. In this study, we characterized the proteins derived from these three genes and examined the impact of individual gene deletions on viral pathogenesis. The M139, M140, and M141 gene products were identified as early proteins that localize to both the nucleus and cytoplasm in infected cells. Gene M139 encodes two proteins, of 72 and 61 kDa, while M140 and M141 each encode a single protein of 56 (pM140) and 52 (pM141) kDa, respectively. No role for the M139 proteins in MCMV replication in macrophages or mice was determined in these studies. In contrast, deletion of either M140 or M141 resulted in impaired MCMV replication in macrophages and spleen tissue. Replication of the M140 deletion mutant was significantly more impaired than that of the virus lacking M141. Further analyses revealed that the absence of the pM140 adversely affected pM141 levels by rendering the latter protein unstable. Since the replication defect due to deletion of M140 was more profound than could be explained by the reduced half-life of pM141, pM140 must exert an additional, independent function in mediating efficient replication of MCMV in macrophages and spleen tissue. These data indicate that the US22 genes M140 and M141 function both cooperatively and independently to regulate MCMV replication in a cell type-specific manner and, thus, to influence viral pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.