ArticleThe Journal of clinical investigation2001
FGF-8 in the ventral pharynx alters development of myocardial calcium transients after neural crest ablation.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Systematic review of cardiovascular neurocristopathy-contemporary insights and future perspectives.Frontiers in cardiovascular medicine · 2024Pooled it
- Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development.Nature communications · 2026Article
- Cardiac Neural Crest.Cold Spring Harbor perspectives in biology · 2021Review
- Embryonic aortic arch hemodynamics are a functional biomarker for ethanol-induced congenital heart defects [Invited].Biomedical optics express · 2017Article
- Molecular regulation of cardiomyocyte differentiation.Circulation research · 2015Review
- Connecting teratogen-induced congenital heart defects to neural crest cells and their effect on cardiac function.Birth defects research. Part C, Embryo today : reviews · 2014Review
- Capturing structure and function in an embryonic heart with biophotonic tools.Frontiers in physiology · 2014Review
- Cardiac outflow tract anomalies.Wiley interdisciplinary reviews. Developmental biology · 2013Review
- The neural crest in cardiac congenital anomalies.Differentiation; research in biological diversity · 2012Review
- Vagal neural crest cell migratory behavior: a transition between the cranial and trunk crest.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- FGF8 signaling is chemotactic for cardiac neural crest cells.Developmental biology · 2011Article
- Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate.Development (Cambridge, England) · 2010Article
- Tbx3 is required for outflow tract development.Circulation research · 2008Article
- Retinoic acid deficiency alters second heart field formation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Cardiovascular development and the colonizing cardiac neural crest lineage.TheScientificWorldJournal · 2007Review
- Model systems for the study of heart development and disease. Cardiac neural crest and conotruncal malformations.Seminars in cell & developmental biology · 2007Review
- Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants.Developmental biology · 2006Article
- Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling.Development (Cambridge, England) · 2006Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Cardiac neural crest ablation results in depressed myocardial calcium transients and elevated proliferation in myocardium at a stage when cardiac neural crest cells are not in contact with the myocardium. To test the hypothesis that cardiac neural crest-derived cells, which migrate into the caudal, ventral pharynx at stage 14, block a signal from the ventral pharynx, we cultured stage 12 chick heart tube or myocardial strips in the presence or absence of ventral pharynx. We found that myocardium cultured with ventral pharynx that had not yet contacted neural crest cells had significantly reduced calcium transients and an increased rate of proliferation. Ventral pharynx from intact embryos at a stage when neural crest-derived cells had reached the pharynx had no effect on myocardial calcium transients. Ventral pharynx from neural crest-ablated embryos continued to suppress myocardial calcium transients at this later stage. Myocardium cultured with FGF-2 also showed a significant reduction in calcium transients. An FGF-2-neutralizing Ab reversed the deleterious effect of the ventral pharynx on myocardial calcium transients and proliferation. We therefore examined the expression of FGF-2 and similar FGFs in the ventral pharynx. Only FGF-8 was expressed in a temporospatial pattern that made it a viable candidate for altering the myocardial calcium transient during stages 14-18. In explant cultures, neutralizing Ab for FGF-8 rescued development of the myocardial calcium transient in neural crest-ablated chick embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.