ArticleGut2001
Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease.
Article in Gut, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00561548 (Impact of Anti-TNF Antibodies on the T-lymphocyte and Macrophage Cooperation in the Crohn Disease), which is not on this map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Anti-TNF Antibodies on the T-lymphocyte and Macrophage Cooperation in the Crohn Disease
Who cites it
46 citing papers in PubMed, 132 citations in OpenAlex.
- Elevated caspase 3 expression correlates with severe inflammation in Crohn's disease.European journal of histochemistry : EJH · 2026Article
- Decreased gene expression of interleukin 2 receptor subunit γ (CD132) in tissues of patients with Crohn's disease.World journal of gastroenterology · 2025Article
- Catalase inhibition can modulate the ability of peripheral blood T cells to undergo apoptosis in Crohn's disease.Clinical and experimental immunology · 2024Article
- Variants of the CASP9 gene as candidate markers for primary response to anti-TNF therapy in Crohn's disease patients.Journal of applied genetics · 2023Article
- Interaction between mitochondria and microbiota modulating cellular metabolism in inflammatory bowel disease.Journal of molecular medicine (Berlin, Germany) · 2023Review
- The Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease.Frontiers in immunology · 2022Review
- Spatiotemporal regulation of galectin-1-induced T-cell death in lamina propria from Crohn's disease and ulcerative colitis patients.Apoptosis : an international journal on programmed cell death · 2021Article
- Emerging Pathological Engagement of Ferroptosis in Gut Diseases.Oxidative medicine and cellular longevity · 2021Review
- Suppression of Inflammatory Cytokines Expression with Bitter Melon (Journal of translational internal medicine · 2020Article
- INTERACTIONS AMONG INTERLEUKIN-6, C-REACTIVE PROTEIN AND INTERLEUKIN-6 (-174) G/C POLYMORPHISM IN THE PATHOGENESIS OF CROHN'S DISEASE AND ULCERATIVE COLITIS.Acta clinica Croatica · 2020Article
- Is Polymorphism in the Apoptosis and Inflammatory Pathway Genes Associated With a Primary Response to Anti-TNF Therapy in Crohn's Disease Patients?Frontiers in pharmacology · 2020Article
- Can molecular stratification improve the treatment of inflammatory bowel disease?Pharmacological research · 2019Review
- BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice.Clinical and experimental immunology · 2018Article
- Peripheral Lymphocytes of Patients with Inflammatory Bowel Disease Have Altered Concentrations of Key Apoptosis Players: Preliminary Results.BioMed research international · 2018Article
- Mesenchymal stem cells and their therapeutic applications in inflammatory bowel disease.Oncotarget · 2017Review
- Disturbances in apoptosis of lamina propria lymphocytes in Crohn's disease.Archives of medical science : AMS · 2015Article
- Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression.Clinical and experimental immunology · 2015Article
- Is the Prevalence of Celiac Disease Higher than the General Population in Inflammatory Bowel Diseaese?Middle East journal of digestive diseases · 2015Article
- Role of DOR-β-arrestin1-Bcl2 signal transduction pathway and intervention effects of oxymatrine in ulcerative colitis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Article
- Cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium.BioMed research international · 2014Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundActivated T cells are more susceptible to apoptosis than resting T cells. As intestinal T cells normally exhibit a higher state of activation, increased apoptosis may be necessary to maintain immune homeostasis in the specialised microenvironment of the mucosa. On the other hand, in Crohn's disease (CD) mucosal T cells are resistant to apoptosis, suggesting abnormal regulation of cell death mechanisms.
aimsTo investigate differences in expression of anti- and proapoptotic Bcl-2 family proteins, key regulators of apoptosis, between circulating and mucosal T cells, and possible alterations in CD. PATIENTS AND
methodsLamina propria T cells (LPT) were isolated from 10 control, seven CD, and eight ulcerative colitis (UC) patients, and peripheral blood T cells (PBT) from healthy volunteers. Purified T cells were stained intracellularly for Bcl-2, Bcl-x(L), and Bax, and mean fluorescence intensity measured by flow cytometry.
resultsCompared with PBT, the expression level of Bcl-2 and Bax, but not Bcl-x(L), was significantly greater in LPT, resulting in lower Bcl-x(L)/Bax ratios. In PBT, Bax expression was highly and significantly correlated with both Bcl-2 and Bcl-x(L), but correlation with Bcl-2 was absent in LPT. Bax expression in CD, but not UC, LPT was significantly lower than in control LPT, resulting in a significantly higher Bcl-x(L)/Bax ratio. The significant correlation of Bcl-x(L) to Bax was preserved in CD, but not UC, LPT.
conclusionsRegulation of Bcl-2 family protein expression differs between circulating and mucosal T cells, probably underlying diverse survival potentials. In CD LPT, a low Bax expression and a high Bcl-x(L)/Bax ratio favour resistance to apoptosis and may contribute to the chronicity of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.