ArticleNucleic acids research2001
The RNA-binding specificity of the mouse Dazl protein.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 83 citations in OpenAlex.
- Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes.Stem cell reports · 2021Article
- Whole-Transcriptome Sequencing-Based Analysis ofInternational journal of molecular sciences · 2020Article
- The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.Nature communications · 2020Article
- Dazl determines primordial follicle formation through the translational regulation of Tex14.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- DAZL is a master translational regulator of murine spermatogenesis.National science review · 2019Article
- Requirement of the 3'-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development.PLoS genetics · 2018Article
- RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary.Molecular human reproduction · 2017Article
- Efficient generation of transgenic reporter strains and analysis of expression patterns in Caenorhabditis elegans using library MosSCI.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis.Molecular biology of the cell · 2016Article
- A premeiotic function for boule in the planarian Schmidtea mediterranea.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Is there a role for DAZL in human female fertility?Molecular human reproduction · 2016Article
- DAZ Family Proteins, Key Players for Germ Cell Development.International journal of biological sciences · 2015Review
- DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells.Stem cell reports · 2014Article
- Article
- Bioinformatic identification of novel elements potentially involved in messenger RNA fate control during spermatogenesis.Biology of reproduction · 2012Article
- Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.Genes & development · 2011Article
- The roles of the DAZ family in spermatogenesis: More than just translation?Spermatogenesis · 2011Article
- HuB (elavl2) mRNA is restricted to the germ cells by post-transcriptional mechanisms including stabilisation of the message by DAZL.PloS one · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DAZ is an RNA-binding protein encoded by a region on the Y chromosome implicated in infertility, and DAZ-like (Dazl) proteins are master regulators of germ line gene expression in all animals. In mice Dazl is only expressed in germ cells and is necessary for meiosis. A dual approach was taken to understand the RNA-binding specificity of the Dazl protein: (i) traditional SELEX and (ii) a novel tri-hybrid screen. Both approaches led to the same conclusion, namely that Dazl binds oligo(U) stretches interspersed by G or C residues. In a directed tri-hybrid assay the strongest interaction was with the consensus (GUn)n. This motif is found in the 5' UTR of CDC25C whose homologue is thought to be the target of Boule, the Dazl homologue in flies. CDC25C 5' UTR also interacted specifically with Dazl in vitro. The tri-hybrid screen retrieved UTRs of known genes that may be physiological substrates of Dazl.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.