Evidence map›Paper›PMID 11410649›Full record

ReviewNucleic acids research2001

Survey and summary: The applications of universal DNA base analogues.

D Loakes

Open access · bronzeAbstract readReview
In one paragraph

Review in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 177 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Fluorogenic PNA probes.Beilstein journal of organic chemistry · 2018
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Current knowledge on pancreatic cancer.Frontiers in oncology · 2012
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Evolving a polymerase for hydrophobic base analogues.Journal of the American Chemical Society · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

D LoakesMedical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. dml@mrc-lmb.cam.ac.uk
MRC Laboratory of Molecular Biology · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A universal base analogue forms 'base pairs' with each of the natural DNA/RNA bases with little discrimination between them. A number of such analogues have been prepared and their applications as biochemical tools investigated. Most of these analogues are non-hydrogen bonding, hydrophobic, aromatic 'bases' which stabilise duplex DNA by stacking interactions. This review of the literature of universal bases (to 2000) details the analogues investigated, and their uses and limitations are discussed.

Indexed as

Base PairingBase SequenceDNADNA PrimersDNA ProbesHydrogen BondingHypoxanthineNucleic Acid DenaturationNucleosidesNucleotidesPyrrolesThermodynamics3-nitropyrroleDNADNA PrimersDNA ProbesHypoxanthineNucleosidesNucleotidesPyrrolestriplex DNA

Identifiers

PMID11410649
PMCPMC55727
OpenAlexW2135343804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.