ArticleThe Journal of physiology2001
Modulation of the Ca(2+)-induced Ca(2+) release cascade by beta-adrenergic stimulation in rat ventricular myocytes.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Autonomic control of ventricular function in health and disease: current state of the art.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Review
- Fir(e)ing the Rhythm: Inflammatory Cytokines and Cardiac Arrhythmias.JACC. Basic to translational science · 2023Review
- Article
- Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS.Basic research in cardiology · 2020Article
- SERCA Activity Controls the Systolic Calcium Increase in the Nucleus of Cardiac Myocytes.Frontiers in physiology · 2019Article
- Spontaneous inward currents reflecting oscillatory activation of Na⁺/Ca²⁺ exchangers in human embryonic stem cell-derived cardiomyocytes.Pflugers Archiv : European journal of physiology · 2016Article
- The nervous heart.Progress in biophysics and molecular biology · 2016Review
- HLA Class I Depleted hESC as a Source of Hypoimmunogenic Cells for Tissue Engineering Applications.Tissue engineering. Part A · 2015Article
- Sex differences in mechanisms of cardiac excitation-contraction coupling.Pflugers Archiv : European journal of physiology · 2013Review
- The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism.Endocrinology · 2008Article
- Local calcium release activation by DHPR calcium channel openings in rat cardiac myocytes.The Journal of physiology · 2008Article
- Protein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytes.The Journal of physiology · 2007Article
- Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Excitation-contraction coupling in Na+-Ca2+ exchanger knockout mice: reduced transsarcolemmal Ca2+ flux.Circulation research · 2005Article
- Excitation-contraction coupling gain and cooperativity of the cardiac ryanodine receptor: a modeling approach.Biophysical journal · 2005Article
- Synergistic interactions between Ca2+ entries through L-type Ca2+ channels and Na+-Ca2+ exchanger in normal and failing rat heart.The Journal of physiology · 2005Article
- Paradoxical SR Ca2+ release in guinea-pig cardiac myocytes after beta-adrenergic stimulation revealed by two-photon photolysis of caged Ca2+.The Journal of physiology · 2005Article
- Modeling the actions of beta-adrenergic signaling on excitation--contraction coupling processes.Annals of the New York Academy of Sciences · 2004Article
- Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger.The Journal of physiology · 2004Article
- Mice overexpressing the cardiac sodium-calcium exchanger: defects in excitation-contraction coupling.The Journal of physiology · 2004Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
1. To define the sub-cellular mechanisms of modulation of cardiac excitation-contraction (E-C) coupling by the beta-adrenergic pathway, we carried out confocal Ca(2+) imaging in conjunction with recordings of inward Ca(2+) current in fluo-3-loaded patch-clamped rat ventricular myocytes. 2. Isoproterenol (isoprenaline; ISO) increased the amplitude of the inward Ca(2+) current and the globally measured intracellular Ca(2+) transients. The gain of calcium-induced calcium release (CICR) was increased at all membrane potentials but especially at positive membrane potentials (> +30 mV). ISO dramatically broadened the bell-shaped voltage dependence of intracellular Ca(2+) transients by shifting the descending portion of the curve to very high membrane potentials. 3. The number of local release events (solitary sparks and conglomerates of overlapping sparks) induced by depolarizing steps to +30 mV was increased significantly by ISO. This potentiation of events was due to increased trigger calcium current (I(Ca)) as well the enhanced ability of I(Ca) to induce release. The amplitude and duration of solitary sparks were increased in the presence of ISO. In addition, ISO dramatically increased the proportion and the size ('mass') of clustered events. 4. Exclusion of Na(+) from the intra- and extracellular solutions prevented ISO from enhancing the ability of I(Ca) to trigger sparks. 5. We conclude that beta-adrenergic stimulation enhances the gain of the CICR cascade by increasing the fidelity of dihydropyridine receptor (DHPR)--ryanodine receptor (RyR) coupling and by promoting cross-activation of RyRs in neighbouring release sites. Reverse Na(+)--Ca(2+) exchange (NCX) appears to play a role in the beta-adrenergic enhancement of CICR by effectively contributing to the Ca(2+) trigger.
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