ArticleThe Journal of physiology2001
Photolysis-induced suppression of inhibition in rat hippocampal CA1 pyramidal neurons.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Space and Time Coherent Mapping for Subcellular Resolution of Imaging Mass Spectrometry.Cells · 2022Article
- Cannabinoid-mediated short-term plasticity in hippocampus.Journal of computational neuroscience · 2014Article
- Self-tuning of inhibition by endocannabinoids shapes spike-time precision in CA1 pyramidal neurons.Journal of neurophysiology · 2013Article
- CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition.PloS one · 2013Article
- Cellular signal mechanisms of reward-related plasticity in the hippocampus.Neural plasticity · 2012Review
- Sustained firing of cartwheel cells in the dorsal cochlear nucleus evokes endocannabinoid release and retrograde suppression of parallel fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Endocannabinoids differentially modulate synaptic plasticity in rat hippocampal CA1 pyramidal neurons.PloS one · 2010Article
- Review
- Somatic spikes regulate dendritic signaling in small neurons in the absence of backpropagating action potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Article
- Sustained elevation of dendritic calcium evokes widespread endocannabinoid release and suppression of synapses onto cerebellar Purkinje cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Endocannabinoid signaling dynamics probed with optical tools.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Endocannabinoid-mediated short-term synaptic plasticity: depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE).British journal of pharmacology · 2004Review
- Photolysis of postsynaptic caged Ca2+ can potentiate and depress mossy fiber synaptic responses in rat hippocampal CA3 pyramidal neurons.Journal of neurophysiology · 2004Article
- Calcium dependence of retrograde inhibition by endocannabinoids at synapses onto Purkinje cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Short-term retrograde inhibition of GABAergic synaptic currents in rat Purkinje cells is mediated by endogenous cannabinoids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. Whole cell patch clamp recording, Ca(2+) measurement with ratiometric fluorescent dyes and photolysis of caged Ca(2+) were combined to investigate the depolarization- and photolysis-induced suppression of inhibition (DSI and PSI) in rat hippocampal CA1 pyramidal cells. 2. A 5-s depolarization from -70 mV to 0 mV or a 6-s photolysis of nitrophenyl-EGTA (NPE) in cell bodies could each depress the frequency of spontaneous inhibitory postsynaptic currents (IPSCs) and the amplitude of evoked IPSCs while elevating intracellular Ca(2+) concentration ([Ca(2+)](i)). 3. Within a cell the elevation of [Ca(2+)](i) induced by depolarization was inversely related to that induced by photolysis, suggesting that higher [NPE] is more effective in releasing caged Ca(2+) but also increases buffer capacity to reduce [Ca(2+)](i) rises caused by Ca(2+) influx through voltage-dependent Ca(2+) channels. 4. Both DSI and PSI were linearly related to [Ca(2+)](i), with a 50 % reduction in transmission occurring at about 3.6--3.9 microM. 5. [Ca(2+)](i) recovered more quickly than DSI, indicating that the duration of DSI is not set simply by the duration of [Ca(2+)](i) elevation, but rather entails other rate-limiting processes. 6. We conclude that DSI is activated by micromolar [Ca(2+)](i) acting far from sites of Ca(2+) entry through channels in the plasma membrane.
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