ArticleMolecular biology of the cell2001
Involvement of p38 in apoptosis-associated membrane blebbing and nuclear condensation.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 120 citations in OpenAlex.
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- Nogo-A-Δ20/EphA4 interaction antagonizes apoptosis of neural stem cells by integrating p38 and JNK MAPK signaling.Journal of molecular histology · 2021Article
- TAK1 is involved in sodium L-lactate-stimulated p38 signaling and promotes apoptosis.Molecular and cellular biochemistry · 2021Article
- Protective effect of ginsenoside Rb1 against tacrolimus-induced apoptosis in renal proximal tubular LLC-PK1 cells.Journal of ginseng research · 2018Article
- Downregulation of MMP1 in MDS-derived mesenchymal stromal cells reduces the capacity to restrict MDS cell proliferation.Scientific reports · 2017Article
- Per2 participates in AKT-mediated drug resistance in A549/DDP lung adenocarcinoma cells.Oncology letters · 2017Article
- ROCK inhibitor reduces Myc-induced apoptosis and mediates immortalization of human keratinocytes.Oncotarget · 2016Article
- Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment.Oncotarget · 2016Review
- TRPV4 Regulates Breast Cancer Cell Extravasation, Stiffness and Actin Cortex.Scientific reports · 2016Article
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- Dasatinib accelerates valproic acid-induced acute myeloid leukemia cell death by regulation of differentiation capacity.PloS one · 2014Article
- Expression and activation of mitogen-activated protein kinases in matured porcine oocytes under thermal stress.The Journal of reproduction and development · 2014Article
- Signalling mechanisms involved in renal pathological changes during cisplatin-induced nephropathy.European journal of clinical pharmacology · 2013Review
- Salicylate selectively kills cochlear spiral ganglion neurons by paradoxically up-regulating superoxide.Neurotoxicity research · 2013Article
- Regulation of endothelial MAPK/ERK signalling and capillary morphogenesis by low-amplitude electric field.Journal of the Royal Society, Interface · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stress-activated protein kinase p38 is often induced by cytotoxic agents, but its contribution to cell death is ill defined. In Rat-1 cells, we found a strong correlation between activation of p38 and induction of c-Myc-dependent apoptosis. In cells with deregulated c-Myc expression but not in control cells, cis-diamminedichloroplatinum induced p38 activity and typical features of apoptosis, including internucleosomal DNA degradation, induction of caspase activities, and both nuclear (nuclear condensation and fragmentation) and extranuclear (cell blebbing) morphological alterations. The pan-caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone did not block p38 activation and the p38 inhibitor SB203580 had no detectable effect on the activation of caspases or the in vivo cleavage of several caspase substrates, suggesting that p38 and caspase activation can contribute distinct features of apoptosis. Accordingly, we found that cell blebbing was independent of caspase activity and, rather, depended on p38-sensitive changes in microfilament dynamics likely mediated by heat shock protein 27 phosphorylation. Furthermore, p38 activity contributed to both caspase-dependent and caspase-independent nuclear condensation and fragmentation, suggesting a role in an early event triggering both mechanisms of apoptosis or sensitizing the cells to the action of both types of apoptosis executioners. Inhibiting p38 also resulted in a significant enhancement in cell survival estimated by colony formation. This capacity to modulate the sensitivity to apoptosis in cells with deregulated c-Myc expression suggests an important role for p38 in tumor cell killing by chemotherapeutic agents.
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