ArticleAntimicrobial agents and chemotherapy2001
Prospective study of Candida species in patients at a comprehensive cancer center.
Article in Antimicrobial agents and chemotherapy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Clinical factors associated with fluconazole resistance in oral Candida from xerostomic head and neck cancer patients.Odontology · 2026Article
- The oral microbiota in oral squamous cell carcinoma: unravelling mechanisms and clinical potential.Cancer cell international · 2026Review
- ASSESSMENT OF ORO-DENTAL HEALTH PARAMETERS, FUNGAL INFECTION AND THE SEVERITY OF CHEMOTHERAPY INDUCED - ORAL MUCOSITIS: FINDINGS FROM A SOUTHWESTERN NIGERIAN TERTIARY CARE CENTRE.Annals of Ibadan postgraduate medicine · 2025Article
- Diagnosis and Treatment Challenges ofCase reports in infectious diseases · 2024Article
- Review
- Evaluation of Candidiasis in Upper-Aerodigestive Squamous Cell Carcinoma Patients-A Clinico-Mycological Aspect.International journal of environmental research and public health · 2022Article
- Antifungal activity of liriodenine on agents of systemic mycoses, with emphasis on the genusThe journal of venomous animals and toxins including tropical diseases · 2020Article
- Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization.Developmental cell · 2019Article
- FK506 Resistance ofAntimicrobial agents and chemotherapy · 2019Article
- Species distribution and susceptibility profiles of Candida species isolated from vulvovaginal candidiasis, emergence of C. lusitaniae.Current medical mycology · 2019Article
- Candidal Species Identification in Malignant and Potentially Malignant Oral Lesions with Antifungal Resistance Patterns.Contemporary clinical dentistry · 2018Article
- Vulvovaginal candidiasis: species distribution of Candida and their antifungal susceptibility pattern.BMC women's health · 2018Article
- Epidemiological Study onOsong public health and research perspectives · 2017Article
- Opportunistic Microorganisms in Oral Cavity According to Treatment Status in Head and Neck Cancer Patients.Journal of clinical and diagnostic research : JCDR · 2017Article
- Influence of cancer treatment on the Candida albicans isolated from the oral cavities of cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Candida infections among neutropenic patients.Caspian journal of internal medicine · 2016Article
- Oral Candidiasis among Cancer Patients Attending a Tertiary Care Hospital in Chennai, South India: An Evaluation of Clinicomycological Association and Antifungal Susceptibility Pattern.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2016Article
- Oropharyngeal candidiasis in children with lymphohematopoietic malignancies in Mashhad, Iran.Current medical mycology · 2015Article
- Design and evaluation of peptide nucleic acid probes for specific identification of Candida albicans.Journal of clinical microbiology · 2015Article
- Ultrasensitive rapid detection of human serum antibody biomarkers by biomarker-capturing viral nanofibers.ACS nano · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since most nosocomial systemic yeast infections arise from the endogenous flora of the patient, we prospectively evaluated the species stratification and antifungal susceptibility profile of Candida spp. associated with heavy colonization and systemic infection in patients at Memorial Sloan-Kettering Cancer Center in New York. A total of 349 Candida isolates were obtained from 223 patients during the later half of 1998. Cancer was the most common underlying disease, occurring in 91% of the patients, including 61.8% with organ and 23.7% with hematological malignancies; 4.4% of the patients had AIDS. Candida albicans was the predominant species (67.3%); among 114 non-albicans Candida spp., C. glabrata (45.6%) was the most frequent, followed by C. tropicalis (18.4%), C. parapsilosis (16.6%), and C. krusei (9.6%). The overall resistance to triazole-based agents among all yeast isolates was 9.4 and 10.8% for fluconazole and itraconazole, respectively. A total of 5% of C. albicans strains were resistant to triazole antifungals, whereas 30.8 and 46.2% of C. glabrata strains were resistant to fluconazole (MIC > or = 64 microg/ml) and itraconazole (MIC > or = 1 microg/ml), respectively. A significant association was observed between prior treatment with triazole and isolation of fluconazole-resistant C. albicans (P = 0.005, OR 36), although this relationship was not seen in C. glabrata isolates (P = 0.4). This study reinforces the importance of periodic, prospective surveillance of clinical fungal isolates to determine appropriate prophylactic, empiric, and preemptive antifungal therapy for the highly susceptible patient population.
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