ArticleJournal of endocrinological investigation2001
Prevalence of silent celiac disease in patients with autoimmune thyroiditis from Northern Sardinia.
Article in Journal of endocrinological investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Celiac disease among at-risk individuals in Saudi Arabia.Saudi medical journal · 2019Pooled it
- Type 3 autoimmune polyglandular syndrome (APS-3) or type 3 multiple autoimmune syndrome (MAS-3): an expanding galaxy.Journal of endocrinological investigation · 2023Review
- Review
- Celiac Disease Screening for High-Risk Groups: Are We Doing It Right?Digestive diseases and sciences · 2020Review
- Current Evidence on the Efficacy of Gluten-Free Diets in Multiple Sclerosis, Psoriasis, Type 1 Diabetes and Autoimmune Thyroid Diseases.Nutrients · 2020Review
- Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease.Archives of medical science : AMS · 2018Article
- Article
- Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel Therapies.Frontiers in pediatrics · 2018Review
- Endocrine manifestations in celiac disease.World journal of gastroenterology · 2016Review
- Assessment of coeliac disease prevalence in patients with Down syndrome in Poland - a multi-centre study.Przeglad gastroenterologiczny · 2016Article
- Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2014Article
- Frequency of celiac disease in patients with hypothyroidism.Journal of thyroid research · 2012Article
- Risk assessment does not explain high prevalence of gestational diabetes mellitus in a large group of Sardinian women.Reproductive biology and endocrinology : RB&E · 2008Article
- Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report.Reproductive biology and endocrinology : RB&E · 2008Article
- Celiac disease and autoimmune thyroid disease.Clinical medicine & research · 2007Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Celiac disease (CD) is frequently associated with other autoimmune diseases such as Type 1 diabetes mellitus, autoimmune thyroiditis (AT), and Addison's disease. The frequency of these associations varies with the populations studied. We conducted this study to ascertain the prevalence of CD in patients with AT from Sardinia, an area with a very high prevalence of CD. To this aim, 297 consecutive patients with AT (as defined by elevated antithyroid antibody levels and a positive ultrasound scan) were studied. Immunoglobulin A and G-class antigliadin antibodies were assayed in serum; if either or both were positive, antiendomysium antibodies were determined. If two markers were positive, serum ferritin, folate, and vitamin B12 levels were measured and jejunal biopsy was suggested. Thirteen out of the 14 patients who showed at least two positive markers consented to jejunal biopsy and all of them showed histological features of CD. The prevalence of CD in AT patients was 4-fold greater than that observed in the general population (4.37 vs 1.06%, p<0.0001). Ferritin was low in 6 and vitamin B12 in 2 out of 13 patients; serum folates were normal in all patients. Molecular typing of HLA class II alleles showed an increased frequency of the extended haplotype DRB1*0301/DQA1*0501/DQB1*0201. None of our patients had a history of gastrointestinal symptoms. We confirm the increased prevalence of silent CD in patients with AT. Patients with AT ought to be regarded as a high-risk group for CD and should be screened routinely for it; if negative, screening tests should be repeated at regular intervals.
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