ArticleThe EMBO journal2001
Transcript analysis of 1003 novel yeast genes using high-throughput northern hybridizations.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- From Petri Plates to Petri Nets, a revolution in yeast biology.FEMS yeast research · 2022Article
- Synergistic effects of TOR and proteasome pathways on the yeast transcriptome and cell growth.Open biology · 2013Article
- Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans.Fungal genetics and biology : FG & B · 2011Article
- The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis.The Journal of biological chemistry · 2010Article
- Glucose promotes stress resistance in the fungal pathogen Candida albicans.Molecular biology of the cell · 2009Article
- Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals.Molecular microbiology · 2009Article
- Article
- The Kluyveromyces lactis CPY homologous genes: cloning and characterization of the KlPCL1 gene.Folia microbiologica · 2008Article
- Global role of the protein kinase Gcn2 in the human pathogen Candida albicans.Eukaryotic cell · 2005Article
- A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans.Molecular biology of the cell · 2004Article
- Widespread selection for local RNA secondary structure in coding regions of bacterial genes.Genome research · 2003Article
- A model-based analysis of microarray experimental error and normalisation.Nucleic acids research · 2003Article
- Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans.The EMBO journal · 2002Article
- Comparison of RNA expression profiles based on maize expressed sequence tag frequency analysis and micro-array hybridization.Plant physiology · 2002Article
- Functional genomics: lessons from yeast.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2002Article
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Authors and funding
22 authors.
Funding
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Abstract
The expression of 1008 open reading frames (ORFs) from the yeast Saccharomyces cerevisiae has been examined under eight different physiological conditions, using classical northern analysis. These northern data have been compared with publicly available data from a microarray analysis of the diauxic transition in S.cerevisiae. The results demonstrate the importance of comparing biologically equivalent situations and of the standardization of data normalization procedures. We have also used our northern data to identify co-regulated gene clusters and define the putative target sites of transcriptional activators responsible for their control. Clusters containing genes of known function identify target sites of known activators. In contrast, clusters comprised solely of genes of unknown function usually define novel putative target sites. Finally, we have examined possible global controls on gene expression. It was discovered that ORFs that are highly expressed following a nutritional upshift tend to employ favoured codons, whereas those overexpressed in starvation conditions do not. These results are interpreted in terms of a model in which competition between mRNA molecules for translational capacity selects for codons translated by abundant tRNAs.
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