ArticleThe EMBO journal2001
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 116 citations in OpenAlex.
- Host-transposon mutualism supports regeneration in planarians.Developmental cell · 2026Article
- Modeling Necroptotic and Pyroptotic Signaling inBiomolecules · 2025Review
- Proteomic analysis discovers potential biomarkers of early traumatic axonal injury in the brainstem.International journal of legal medicine · 2024Article
- Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface.Life science alliance · 2023Article
- A long way to go: caspase inhibitors in clinical use.Cell death & disease · 2021Review
- Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein.Cell death and differentiation · 2020Article
- Future Therapeutic Directions for Smac-Mimetics.Cells · 2020Review
- Role of XIAP gene overexpressed bone marrow mesenchymal stem cells in the treatment of cerebral injury in rats with cerebral palsy.Cancer cell international · 2019Article
- Impact of inhibitor of apoptosis proteins on immune modulation and inflammation.Immunology and cell biology · 2017Review
- Regulation of PI3K/Akt dependent apoptotic markers during b virus infection of human and macaque fibroblasts.PloS one · 2017Article
- A Study on Apoptosis and Anti-apoptotic Status in Wilson Disease.Molecular neurobiology · 2016Article
- FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration.Scientific reports · 2016Article
- Involvement of CASP3 promoter polymorphism (-1337 C > G) in the development and progression of non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis.American journal of respiratory cell and molecular biology · 2016Article
- Ubiquitin-Mediated Regulation of Cell Death, Inflammation, and Defense of Homeostasis.Current topics in developmental biology · 2015Review
- Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase.Cell death and differentiation · 2014Article
- Regulation of cell migration, invasion and metastasis by IAP proteins and their antagonists.Oncogene · 2014Review
- FAIM-L is an IAP-binding protein that inhibits XIAP ubiquitinylation and protects from Fas-induced apoptosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Targeting IAP proteins for therapeutic intervention in cancer.Nature reviews. Drug discovery · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
XIAP is a mammalian inhibitor of apoptosis protein (IAP). To determine residues within the second baculoviral IAP repeat (BIR2) required for inhibition of caspase 3, we screened a library of BIR2 mutants for loss of the ability to inhibit caspase 3 toxicity in the yeast Schizosaccharomyces pombe. Four of the mutations, not predicted to affect the structure of the BIR fold, clustered together on the N-terminal region that flanks BIR2, suggesting that this is a site of interaction with caspase 3. Introduction of these mutations into full-length XIAP reduced caspase 3 inhibitory activity up to 500-fold, but did not affect its ability to inhibit caspase 9 or interact with the IAP antagonist DIABLO. Furthermore, these mutants retained full ability to inhibit apoptosis in transfected cells, demonstrating that although XIAP is able to inhibit caspase 3, this activity is dispensable for inhibition of apoptosis by XIAP in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.