ArticleAnnals of the rheumatic diseases2001
Assessment of phalangeal bone loss in patients with rheumatoid arthritis by quantitative ultrasound.
Article in Annals of the rheumatic diseases, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 37 citations in OpenAlex.
- Clinical utilities of quantitative ultrasound in osteoporosis associated with inflammatory rheumatic diseases.Quantitative imaging in medicine and surgery · 2018Review
- Hand bone mass in rheumatoid arthritis: A review of the literature.World journal of orthopedics · 2015Review
- Quantitative ultrasound in the assessment of skeletal status.European radiology · 2009Review
- The correlation between phalangeal quantitative ultrasonography and dual energy x-ray absorptiometry in women with premature ovarian failure.McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students · 2008Article
- Hand bone loss in early undifferentiated arthritis: evaluating bone mineral density loss before the development of rheumatoid arthritis.Annals of the rheumatic diseases · 2006Article
- Use of digital x ray radiogrammetry in the assessment of joint damage in rheumatoid arthritis.Annals of the rheumatic diseases · 2006Article
- A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells.Annals of the rheumatic diseases · 2004Article
- Bone status in rheumatoid arthritis assessed at peripheral sites by three different quantitative ultrasound devices.Clinical rheumatology · 2004Article
- Assessing periarticular bone mineral density in patients with early psoriatic arthritis or rheumatoid arthritis.Annals of the rheumatic diseases · 2002Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePeriarticular osteopenia is an early radiological sign of rheumatoid arthritis (RA). Quantitative ultrasound (QUS) devices have recently been shown to be useful for assessing osteoporosis. In this study the capability of a transportable and easy to use QUS device to detect skeletal impairment of the finger phalanges in patients with RA was investigated.
methodsIn a cross sectional study 83 women (30 controls, 29 with glucocorticosteroid (GC) treated RA, and 24 with GC treated vasculitis) were examined. QUS measurements were obtained at the metaphyses of the proximal phalanges II-V and directly at the proximal interphalangeal joints II-IV with a DBM Sonic 1200 (IGEA, Italy) QUS device. Amplitude dependent speed of sound (AD-SoS) was evaluated. In 23 of the patients with RA, hand radiographs were evaluated.
resultsSignificant differences between patients with RA and the other groups were found for AD-SoS at both measurement sites. Compared with age matched controls, the AD-SoS of patients with RA was lowered by two and three standard deviations at the metaphysis and joint, respectively. Fingers of patients with RA without erosions (Larsen score 0-I) already had significantly decreased QUS values, which deteriorated further with the development of erosions (Larsen II-V).
conclusionThis study indicates that QUS is sensitive to phalangeal periarticular bone loss in RA. QUS is a quick, simple, and inexpensive method free of ionising radiation that appears to be suited to detection of early stages of periarticular bone loss. Its clinical use in the assessment of early RA should be further evaluated in prospective studies.
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