SynthesisThe Cochrane database of systematic reviews2001
Antibiotics for asymptomatic bacteriuria in pregnancy.
Synthesis in The Cochrane database of systematic reviews, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Antibiotics for asymptomatic bacteriuria in pregnancy.The Cochrane database of systematic reviews · 2019Pooled it
- Bacterial aetiological agents of intra-amniotic infections and preterm birth in pregnant women.Frontiers in cellular and infection microbiology · 2013Pooled it
- Meta-analysis of the significance of asymptomatic bacteriuria in diabetes.Diabetes care · 2011 · on this mapPooled it
- Fetal fibronectin testing for reducing the risk of preterm birth.The Cochrane database of systematic reviews · 2008Pooled it
- Is single-dose fosfomycin trometamol a good alternative for asymptomatic bacteriuria in the second trimesterof pregnancy?International urogynecology journal and pelvic floor dysfunction · 2007Trial
- Reduction in preterm delivery and neonatal mortality after the introduction of antenatal cotrimoxazole prophylaxis among HIV-infected women with low CD4 cell counts.The Journal of infectious diseases · 2006Trial
- Is the Early Screening of Lower Genital Tract Infections Useful in Preventing Adverse Obstetrical Outcomes in Twin Pregnancy?Journal of clinical medicine · 2024Article
- Perirenal abscess as a cause of intrauterine fetal death: A case report.Urology case reports · 2023Article
- Pyelonephritis complicated by a perirenal abscess in a pregnant woman: Exceptional cause of fetal death in utero.Urology case reports · 2022Article
- Assessment of asymptomatic bacteriuria and sterile pyuria among antenatal attendants in hospitals in northern Ghana.BMC pregnancy and childbirth · 2020Article
- Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract.Microbiology spectrum · 2016Review
- Urinary tract infection as a preventable cause of pregnancy complications: opportunities, challenges, and a global call to action.Global advances in health and medicine · 2013Article
- The kidney in pregnancy: A journey of three decades.Indian journal of nephrology · 2012Article
- Acute pyelonephritis in pregnancy: a retrospective descriptive hospital based-study.ISRN obstetrics and gynecology · 2012Article
- Asymptomatic bacteriuria and antibacterial susceptibility patterns in an obstetric population.ISRN obstetrics and gynecology · 2011Article
- Care for women with prior preterm birth.American journal of obstetrics and gynecology · 2010Review
- Closing the Black-White gap in birth outcomes: a life-course approach.Ethnicity & disease · 2010Article
- Nifedipine-induced changes in the electrohysterogram of preterm contractions: feasibility in clinical practice.Obstetrics and gynecology international · 2010Article
- A review of the methodological features of systematic reviews in maternal medicine.BMC medicine · 2007Review
- The role of inflammation and infection in preterm birth.Seminars in reproductive medicine · 2007Review
Corrections and comments
- Updated by
- Update of
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUp to 30% of mothers develop acute pyelonephritis if asymptomatic bacteriuria is untreated. Asymptomatic bacteriuria may have a role in preterm birth or it may be a marker for low socioeconomic status which is associated with low birth weight.
objectivesThe objective of this review was to assess the effect of antibiotic treatment for asymptomatic bacteriuria on persistent bacteriuria during pregnancy, the risk of preterm delivery, and the development of pyelonephritis. SEARCH STRATEGY: I searched the Cochrane Pregnancy and Childbirth Group trials register. Date of last search: December 2000. SELECTION CRITERIA: Randomised trials comparing antibiotic treatment with placebo or no treatment in pregnant women with asymptomatic bacteriuria found on antenatal screening. DATA COLLECTION AND ANALYSIS: Trial quality was assessed. MAIN
resultsFourteen studies were included. Overall the study quality was not strong. Antibiotic treatment compared to placebo or no treatment was effective in clearing asymptomatic bacteriuria (odds ratio 0.07, 95% confidence interval 0.05 to 0.10). The incidence of pyelonephritis was reduced (odds ratio 0.24, 95% confidence interval 0.19 to 0.32). Antibiotic treatment was also associated with a reduction in the incidence of preterm delivery or low birth weight babies (odds ratio 0.60, 95% confidence interval 0.45 to 0.80). REVIEWER'S
conclusionsAntibiotic treatment is effective in reducing the risk of pyelonephritis in pregnancy. An apparent reduction in preterm delivery is consistent with current theories about the role of infection in preterm birth, but this association should be interpreted with caution.
Indexed as
Identifiers
11405965What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.