ArticleBMC medical research methodology2001
Reporting of conflicts of interest in guidelines of preventive and therapeutic interventions.
Article in BMC medical research methodology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Conflicts of interest in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews: associations with recommendations.The Cochrane database of systematic reviews · 2020Pooled it
- Conflict of interest in clinical practice guideline development: a systematic review.PloS one · 2011Pooled it
- A quality assessment of clinical practice guidelines with recommendations for family involvement in the care of individuals diagnosed with schizophrenia, bipolar mood disorder, and major depressive disorder: Critical appraisal utilizing AGREE II.Frontiers in psychiatry · 2022Article
- Financial Conflicts of Interest in Clinical Practice Guidelines: A Systematic Review.Mayo Clinic proceedings. Innovations, quality & outcomes · 2021Review
- Reporting of conflicts of interest and of sponsorship of guidelines in anaesthesiology. A cross-sectional study.PloS one · 2019Article
- Development of rapid guidelines: 1. Systematic survey of current practices and methods.Health research policy and systems · 2018Article
- Reporting of financial conflicts of interest in clinical practice guidelines: a case study analysis of guidelines from the Canadian Medical Association Infobase.BMC health services research · 2016Article
- Declaration and Handling of Conflicts of Interest in Guidelines: A Study of S1 Guidelines From German Specialist Societies From 2010-2013.Deutsches Arzteblatt international · 2015Article
- Does the pharmaceutical industry influence guidelines?: two examples from Germany.Deutsches Arzteblatt international · 2013Article
- Guidelines in cardiac clinical practice: evaluation of their methodological quality using the AGREE II instrument.Journal of the Royal Society of Medicine · 2013Review
- Underreporting of conflicts of interest in clinical practice guidelines: cross sectional study.BMC medical ethics · 2013Article
- Conflicts of interest among authors of clinical practice guidelines for glycemic control in type 2 diabetes mellitus.PloS one · 2013Article
- Conflict of interest disclosures for clinical practice guidelines in the national guideline clearinghouse.PloS one · 2012Article
- Endoscope-assisted submandibular sialadenectomy: a review of outcomes, complications, and ethical concerns.Eplasty · 2010Article
- Production and quality of clinical practice guidelines in Argentina (1994-2004): a cross-sectional study.Implementation science : IS · 2008Article
- Competing interests in development of clinical practice guidelines for diabetes management: Report from a multidisciplinary workshop.Journal of multidisciplinary healthcare · 2008Article
- Improving the use of research evidence in guideline development: 4. Managing conflicts of interests.Health research policy and systems · 2006Article
- Why most published research findings are false.PLoS medicine · 2005Article
- Declaring competing interests. Problem cannot be solved by editors alone.BMJ (Clinical research ed.) · 2001Article
- Undisclosed conflicts of interest among biomedical textbook authors.AJOB empirical bioethicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuidelines published in major medical journals are very influential in determining clinical practice. It would be essential to evaluate whether conflicts of interests are disclosed in these publications. We evaluated the reporting of conflicts of interest and the factors that may affect such disclosure in a sample of 191 guidelines on therapeutic and/or preventive measures published in 6 major clinical journals (Annals of Internal Medicine, BMJ, JAMA, Lancet, New England Journal of Medicine, Pediatrics) in 1979, 1984, 1989, 1994 and 1999.
resultsOnly 7 guidelines (3.7%) mentioned conflicts of interest and all were published in 1999 (17.5% (7/40) of guidelines published in 1999 alone). Reporting of conflicts of interest differed significantly by journal (p=0.026), availability of disclosure policy by the journal (p=0.043), source of funding (p < 0.001) and number of authors (p=0.004). In the entire database of 191 guidelines, a mere 18 authors disclosed a total of 24 potential conflicts of interest and most pertained to minor issues.
conclusionsDespite some recent improvement, reporting of conflicts of interest in clinical guidelines published in influential journals is largely neglected.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.