ArticleMediators of inflammation2001
Increased urinary nitrite, a marker of nitric oxide, in active inflammatory bowel disease.
Article in Mediators of inflammation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 39 citations in OpenAlex.
- Poor Relationship Between Fractionated Exhaled Nitric Oxide and Disease Activity in Eosinophilic Esophagitis.Dysphagia · 2019Trial
- Nitric Oxide in the Intestinal Stem Cell Niche: A Spatial Model of Nitrosative Stress and Clonal Evolution in Colitis-Associated Colorectal Cancer.Digestive diseases and sciences · 2026Review
- Sleep recovery ameliorates submandibular salivary gland inflammation associated with paradoxical sleep deprivation in male Wistar rats.Journal of applied oral science : revista FOB · 2025Article
- The role of oral bacteria in inflammatory bowel disease.Nature reviews. Gastroenterology & hepatology · 2021Review
- Palm Kernel Cake Oligosaccharides Acute Toxicity and Effects on Nitric Oxide Levels Using a Zebrafish Larvae Model.Frontiers in physiology · 2020Article
- Nitric oxide as a potential biomarker in inflammatory bowel disease.Bosnian journal of basic medical sciences · 2013Article
- Immunostimulation in the era of the metagenome.Cellular & molecular immunology · 2011Review
- Nitric oxide and superoxide in rat mesangial cells: modulation by C-reactive protein.Pediatric nephrology (Berlin, Germany) · 2006Article
- Alterations in antioxidant power and levels of epidermal growth factor and nitric oxide in saliva of patients with inflammatory bowel diseases.Digestive diseases and sciencesArticle
- Assessment of fractionated exhaled nitric oxide as a biomarker for the treatment of eosinophilic esophagitis.Allergy and asthma proceedingsArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNitric oxide (NO) production is increased in inflammatory bowel disease (IBD), and measurement of NO metabolites may be useful for monitoring disease activity. AIMS AND
objectivesTo characterise urinary nitrite levels, a stable metabolite of NO, in IBD and to evaluate its potential as a marker of disease activity.
methodsTwelve-hour urinary nitrites were measured by the microplate assay method in 46 patients with IBD (active; n = 32). Urinary samples from 16 healthy individuals served as controls.
resultsIncreased levels of urinary nitrites were found in patients with active IBD compared with those with inactive IBD. Twenty-eight out of 32 patients (87.5%) with active IBD had detectable levels of nitrite in their urine as compared with 2/14 (14.3%) patients with inactive IBD. None of the 16 healthy controls had detectable urinary nitrite. Twelve-hour urinary nitrite in active compared with inactive IBD: 5 0.7 versus 0.1+/-0.04 micromol (P < 0.05). There was good correlation between urinary nitrite and some markers of disease activity in IBD such as C-reactive protein and microalbuminuria but not with erythrocyte sedimentation rate.
conclusionsIncreased levels of nitrite were detected in urine of patients with active IBD, consistent with increased NO synthesis. This simple assay may be exploited as a potential marker of disease activity in IBD.
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