ArticleProceedings of the National Academy of Sciences of the United States of America2001
Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 36 citations in OpenAlex.
- Identification of the transgenic integration site in 2C T cell receptor transgenic mice.Transgenic research · 2018Article
- T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1Frontiers in immunology · 2018Article
- Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Identification of HLA-E-specific alloreactive T lymphocytes: a cell subset that undergoes preferential expansion in mixed lymphocyte culture and displays a broad cytolytic activity against allogeneic cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells.Nature immunology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The H-2Ld alloreactive 2C T cell receptor (TCR) is commonly considered as being positively selected on the H-2Kb molecule. Surprisingly, 2C TCR+ CD8+ single-positive T cells emerge in massive numbers in fetal thymic organ culture originating from 2C transgenic, H-2KbD(b-/-) (2C+KbD(b-/-)) but not in fetal thymic organ culture from beta2-microglobulin(-/-) 2C transgenic animals. Mature CD8+ T cells are observed in newborn but not in adult 2C+KbD(b-/-) mice. These CD8+ T cells express the alpha4beta7 integrin, which allows them to populate the intestine, a pattern of migration visualized by intrathymic injection of FITC and subsequent accrual of FITC-labeled lymphocytes in the gut. We conclude that the 2C TCR is reactive not only with H-2Ld and H-2Kb, but also with nonclassical MHC class I products to enable positive selection of 2C+ T cells in the fetal and newborn thymus and to support their maintenance in the intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.