ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Blockade of endogenous neurotrophic factors prevents the androgenic rescue of rat spinal motoneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Sex Steroids and Brain-Derived Neurotrophic Factor Interactions in the Nervous System: A Comprehensive Review of Scientific Data.International journal of molecular sciences · 2025Review
- Disease AffectsInternational journal of molecular sciences · 2019Article
- Activity-Based Physical Rehabilitation with Adjuvant Testosterone to Promote Neuromuscular Recovery after Spinal Cord Injury.International journal of molecular sciences · 2018Review
- Effects of sex and prenatal androgen manipulations on Onuf's nucleus of rhesus macaques.Hormones and behavior · 2018Article
- The effect of adolescent testosterone on hippocampal BDNF and TrkB mRNA expression: relationship with cell proliferation.BMC neuroscience · 2015Article
- Fat mass and obesity-associated (FTO) protein interacts with CaMKII and modulates the activity of CREB signaling pathway.Human molecular genetics · 2014Article
- Brain-derived neurotrophic factor and androgen interactions in spinal neuromuscular systems.Neuroscience · 2013Review
- Turning sex inside-out: Peripheral contributions to sexual differentiation of the central nervous system.Biology of sex differences · 2012Article
- Trophic effects of brain-derived neurotrophic factor blockade in an androgen-sensitive neuromuscular system.Endocrinology · 2010Article
- Neuroprotective actions of androgens on motoneurons.Frontiers in neuroendocrinology · 2009Review
- The role of neurotrophins in the seasonal-like growth of the avian song control system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The organizational hypothesis and final common pathways: Sexual differentiation of the spinal cord and peripheral nervous system.Hormones and behavior · 2009Review
- The spinal nucleus of the bulbocavernosus: firsts in androgen-dependent neural sex differences.Hormones and behavior · 2008Review
- Androgen and estrogen receptor-mediated mechanisms of testosterone action in male rat pelvic autonomic ganglia.Neuroscience · 2007Article
- Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model.The Journal of clinical investigation · 2006Article
- Effects of Bax gene deletion on muscle and motoneuron degeneration in a sexually dimorphic neuromuscular system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Gonadal steroid attenuation of developing hamster facial motoneuron loss by axotomy: equal efficacy of testosterone, dihydrotestosterone, and 17-beta estradiol.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- The function of neurotrophic factor receptors expressed by the developing adductor motor pool in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Target-derived neurotrophic factors are assumed to regulate motoneuron cell death during development but remain unspecified. Motoneuron cell death in the spinal nucleus of the bulbocavernosus (SNB) of rats extends postnatally and is controlled by androgens. We exploited these features of the SNB system to identify endogenously produced trophic factors regulating motoneuron survival. Newborn female rat pups were treated with the androgen, testosterone propionate, or the oil vehicle alone. In addition, females received trophic factor antagonists delivered either into the perineum (the site of SNB target muscles) or systemically. Fusion molecules that bind and sequester the neurotrophins (trkA-IgG, trkB-IgG, and trkC-IgG) were used to block activation of neurotrophin receptors, and AADH-CNTF was used to antagonize signaling through the ciliary neurotrophic factor receptor-alpha (CNTFRalpha). An acute blockade of trkB, trkC, or CNTFRalpha prevented the androgenic sparing of SNB motoneurons when antagonists were delivered to the perineum. Trophic factor antagonists did not significantly reduce SNB motoneuron number when higher doses were injected systemically. These findings demonstrate a requirement for specific, endogenously produced trophic factors in the androgenic rescue of SNB motoneurons and further suggest that trophic factor interactions at the perineum play a crucial role in masculinization of this neural system.
Indexed as
Identifiers
11404422PMC6762766W2135055500What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.