ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Induction of the plasminogen activator system accompanies peripheral nerve regeneration after sciatic nerve crush.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 100 citations in OpenAlex.
- PXL01 in sodium hyaluronate for improvement of hand recovery after flexor tendon repair surgery: randomized controlled trial.PloS one · 2014Trial
- Intrinsic circadian organization of the spinal cord and dorsal root ganglia.Pain reports · 2026Article
- Overexpression of BDNF and uPA Combined with the Suppression of Von Hippel-Lindau Tumor Suppressor Enhances the Neuroprotective Activity of the Secretome of Human Mesenchymal Stromal Cells in the Model of Intracerebral Hemorrhage.International journal of molecular sciences · 2025Article
- Lactoferrin-derived peptide PXL01 impacts nerve regeneration after sciatic nerve reconstruction in healthy and diabetic rats.Frontiers in cell and developmental biology · 2025Article
- PXL01 alters macrophage response with no effect on axonal outgrowth or Schwann cell response after nerve repair in rats.Regenerative medicine · 2024Article
- IL4 stimulated macrophages promote axon regeneration after peripheral nerve injury by secreting uPA to stimulate uPAR upregulated in injured axons.Cellular and molecular life sciences : CMLS · 2022Article
- Changes in serum angiogenic factors among patients with acute pain and subacute pain.Frontiers in molecular neuroscience · 2022Article
- Muscarinic receptors modulate Nerve Growth Factor production in rat Schwann-like adipose-derived stem cells and in Schwann cells.Scientific reports · 2020Article
- Novel miRNA, miR-sc14, promotes Schwann cell proliferation and migration.Neural regeneration research · 2019Article
- The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1.Frontiers in cellular neuroscience · 2019Review
- The dynamic changes of main cell types in the microenvironment of sciatic nerves following sciatic nerve injury and the influence of let-7 on their distribution.RSC advances · 2018Article
- MiR-340 Regulates Fibrinolysis and Axon Regrowth Following Sciatic Nerve Injury.Molecular neurobiology · 2017Article
- Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats.Chinese journal of integrative medicine · 2017Article
- The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration.Journal of cell science · 2015Article
- tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.Molecular neurobiology · 2014Article
- Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.PloS one · 2014Article
- Role of glial cells in axonal regeneration.Experimental neurobiology · 2013Article
- Extracellular matrix-associated gene expression in adult sensory neuron populations cultured on a laminin substrate.BMC neuroscience · 2013Article
- Article
- Plasminogen activator promotes recovery following spinal cord injury.Cellular and molecular neurobiology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Peripheral nerve regeneration is dependent on the ability of regenerating neurites to migrate through cellular debris and altered extracellular matrix at the injury site, grow along the residual distal nerve sheath conduit, and reinnervate synaptic targets. In cell culture, growth cones of regenerating axons secrete proteases, specifically plasminogen activators (PAs), which are believed to facilitate growth cone movement by digesting extracellular matrices and cell adhesions. In this study, the PA system was shown to be specifically activated in sensory neurons after sciatic nerve crush in adult mice. The number of sensory neurons expressing urokinase PA receptor (uPAR) mRNA levels increased above sham levels by 8 hr after crush, whereas the number of sensory neurons expressing uPA and tissue PA (tPA) mRNAs was significantly increased by 3 d after crush. PA mRNA levels were also increased at the crush site, with uPA mRNA elevated by 8 hr after crush and tPA and uPAR mRNA levels markedly increased by 7 d. PA-dependent enzymatic activity was significantly increased from 1 to 7 d after crush in nerves that had been crushed compared with uncrushed nerves. Immunohistochemistry showed that tPA was localized within regenerating axons of the sciatic nerve. There were no significant changes in plasminogen activator inhibitor 1 activity between crush and sham after the injury. These results clearly demonstrated that after injury the PA system was rapidly induced in sensory neurons, where it may play an important role in nerve regeneration in vivo.
Indexed as
Identifiers
11404419PMC6762730W1565301559What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.