ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
A role of netrin-1 in the formation of the subcortical structure striatum: repulsive action on the migration of late-born striatal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 90 citations in OpenAlex.
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- Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to regulate cerebellar granule neuron germinal zone exit.Nature communications · 2025Article
- Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling.Cell reports · 2024Article
- Long-distance regressive signaling in neural development and disease.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- Epigenomic programming in early fetal brain development.Epigenomics · 2020Article
- Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration.Frontiers in cell and developmental biology · 2020Article
- Involvement of Netrins and Their Receptors in Neuronal Migration in the Cerebral Cortex.Frontiers in cell and developmental biology · 2020Review
- Cell migration promotes dynamic cellular interactions to control cerebral cortex morphogenesis.Nature reviews. Neuroscience · 2019Review
- Parallel Emergence of a Compartmentalized Striatum with the Phylogenetic Development of the Cerebral Cortex.Brain sciences · 2019Review
- The microRNAsThe Journal of biological chemistry · 2019Article
- Loss of Intercalated Cells (ITCs) in the Mouse Amygdala ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Netrin-1 Improves Functional Recovery through Autophagy Regulation by Activating the AMPK/mTOR Signaling Pathway in Rats with Spinal Cord Injury.Scientific reports · 2017Article
- Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway.Frontiers in cellular neuroscience · 2017Article
- An Association Study Between Genetic Polymorphisms in Functional Regions of Five Genes and the Risk of Schizophrenia.Journal of molecular neuroscience : MN · 2016Article
- Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells.Stem cell reports · 2015Article
- Dynamic ordering of early generated striatal cells destined to form the striosomal compartment of the striatum.The Journal of comparative neurology · 2015Article
- Article
- Expression of netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated locomotion-5 homolog B, in rat brain following focal cerebral ischemia reperfusion injury.Neural regeneration research · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian striatum arises in the basal telencephalon and contains morphologically homogenous neurons that can be divided into two distinct compartments, patches and the matrix. During development, patch neurons are generated first to form a striatal primordium. After a large influx of later-born matrix neurons into this region, the unique mosaic arrangement of these two neuronal phenotypes is established. The massive migration of matrix neurons continues during the embryonic period, and they eventually comprise 80-85% of the mature striatum. To elucidate the cellular mechanism or mechanisms underlying this critical event in striatal histogenesis, we examined the migration characteristics of striatal subventricular zone (SVZ) cells at embryonic day 18 when neurogenesis peaks for matrix neurons. Using gel cultures, we show that netrin-1, one of the diffusible guidance cues expressed in the striatal ventricular zone (VZ), exerts a repulsive action on migrating SVZ cells. This effect is blocked in the presence of antibodies against Deleted in colorectal cancer (DCC), a putative receptor for netrin-1. The expression patterns of netrin-1 and DCC strongly suggest the involvement of this effect in the outward migration of SVZ cells into the striatal postmitotic region. Our cell tracing study using living brain slices demonstrates that striatal SVZ cells migrate toward and disperse throughout the striatum, in which they differentiate into phenotypes of striatal projection neurons. We suggest that netrin-1 expressed in the striatal VZ serves to guide the large influx of striatal matrix neurons into the striatal primordium and is thereby involved in the initial formation of fundamental striatal structures.
Indexed as
Identifiers
11404412PMC6762754W1537134194What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.