ArticleGenetics2001
The use of intraallelic variability for testing neutrality and estimating population growth rate.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Sweeps in Space: Leveraging Geographic Data to Identify Beneficial Alleles in Anopheles gambiae.Molecular biology and evolution · 2025Article
- Diversity of CFTR variants across ancestries characterized using 454,727 UK biobank whole exome sequences.Genome medicine · 2024Article
- Article
- An investigation of the statistical power of neutrality tests based on comparative and population genetic data.Molecular biology and evolution · 2009Article
- Linkage disequilibrium--understanding the evolutionary past and mapping the medical future.Nature reviews. Genetics · 2008Review
- A nonparametric test reveals selection for rapid flowering in the Arabidopsis genome.PLoS biology · 2006Article
- Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.American journal of human genetics · 2006Article
- A map of recent positive selection in the human genome.PLoS biology · 2006Article
- Article
- Perspectives on human genetic variation from the HapMap Project.PLoS genetics · 2005Article
- The beta -globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria.American journal of human genetics · 2005Article
- Microsatellite variation and evolution of human lactase persistence.Human genetics · 2005Article
- A population-genetic test of founder effects and implications for Ashkenazi Jewish diseases.American journal of human genetics · 2004Article
- Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K: evidence of genetic drift within the Ashkenazim.American journal of human genetics · 2003Article
- The extent of linkage disequilibrium and haplotype sharing around a polymorphic site.Genetics · 2003Article
- A method for detecting recent selection in the human genome from allele age estimates.Genetics · 2003Article
- Novel multilocus measure of linkage disequilibrium to estimate past effective population size.Genome research · 2003Article
- The genetic legacy of the Mongols.American journal of human genetics · 2003Article
- Polymorphism and divergence for island-model species.Genetics · 2003Article
- Interrogating a high-density SNP map for signatures of natural selection.Genome research · 2002Article
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2 authors.
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Abstract
To better understand the forces affecting individual alleles, we introduce a method for finding the joint distribution of the frequency of a neutral allele and the extent of variability at closely linked marker loci (the intraallelic variability). We model three types of intraallelic variability: (a) the number of nonrecombinants at a linked biallelic marker locus, (b) the length of a conserved haplotype, and (c) the number of mutations at a linked marker locus. If the population growth rate is known, the joint distribution provides the basis for a test of neutrality by testing whether the observed level of intraallelic variability is consistent with the observed allele frequency. If the population growth rate is unknown but neutrality can be assumed, the joint distribution provides the likelihood of the growth rate and leads to a maximum-likelihood estimate. We apply the method to data from published data sets for four loci in humans. We conclude that the Delta32 allele at CCR5 and a disease-associated allele at MLH1 arose recently and have been subject to strong selection. Alleles at PAH appear to be neutral and we estimate the recent growth rate of the European population to be approximately 0.027 per generation with a support interval of (0.017-0.037). Four of the relatively common alleles at CFTR also appear to be neutral but DeltaF508 appears to be significantly advantageous to heterozygous carriers.
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