ArticleGenetics2001
An ancient retrovirus-like element contains hot spots for SINE insertion.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Flying Around in the Genome: Characterization of LINE-1 in Chiroptera.Special publications (Texas Tech University. Museum) · 2019Article
- The dynamic proliferation of CanSINEs mirrors the complex evolution of Feliforms.BMC evolutionary biology · 2014Article
- Characterization of SBEIIa homoeologous genes in bread wheat.Molecular genetics and genomics : MGG · 2012Article
- Article
- Mammalian evolution may not be strictly bifurcating.Molecular biology and evolution · 2010Article
- Mosaic retroposon insertion patterns in placental mammals.Genome research · 2009Article
- An ancient repeat sequence in the ATP synthase beta-subunit gene of forcipulate sea stars.Journal of molecular evolution · 2007Article
- Multiple homoplasious insertions and deletions of a Triticeae (Poaceae) DNA transposon: a phylogenetic perspective.BMC evolutionary biology · 2007Article
- Using genomic data to unravel the root of the placental mammal phylogeny.Genome research · 2007Article
- Retroposed elements as archives for the evolutionary history of placental mammals.PLoS biology · 2006Article
- Short interspersed elements (SINEs) are a major source of canine genomic diversity.Genome research · 2005Article
- Evolutionary implications of multiple SINE insertions in an intronic region from diverse mammals.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Orthologous repeats and mammalian phylogenetic inference.Genome research · 2005Article
- Article
- Genome-wide analysis of the human Alu Yb-lineage.Human genomics · 2004Article
- Saci-1, -2, and -3 and Perere, four novel retrotransposons with high transcriptional activities from the human parasite Schistosoma mansoni.Journal of virology · 2004Article
- Alu elements and hominid phylogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Comprehensive analysis of two Alu Yd subfamilies.Journal of molecular evolution · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Vertebrate retrotransposons have been used extensively for phylogenetic analyses and studies of molecular evolution. Information can be obtained from specific inserts either by comparing sequence differences that have accumulated over time in orthologous copies of that insert or by determining the presence or absence of that specific element at a particular site. The presence of specific copies has been deemed to be an essentially homoplasy-free phylogenetic character because the probability of multiple independent insertions into any one site has been believed to be nil. Mys elements are a type of LTR-containing retrotransposon present in Sigmodontine rodents. In this study we have shown that one particular insert, mys-9, is an extremely old insert present in multiple species of the genus Peromyscus. We have found that different copies of this insert show a surprising range of sizes, due primarily to a continuing series of SINE (short interspersed element) insertions into this locus. We have identified two hot spots for SINE insertion within mys-9 and at each hot spot have found that two independent SINE insertions have occurred at identical sites. These results have major repercussions for phylogenetic analyses based on SINE insertions, indicating the need for caution when one concludes that the existence of a SINE at a specific locus in multiple individuals is indicative of common ancestry. Although independent insertions at the same locus may be rare, SINE insertions are not homoplasy-free phylogenetic markers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.