ArticleGenetics2001
Characterization of the flamenco region of the Drosophila melanogaster genome.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Traffic Jam activates the Flamenco piRNA cluster locus and the Piwi pathway to ensure transposon silencing and Drosophila fertility.Cell reports · 2025Article
- The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility.Nature genetics · 2020Article
- Rapid evolution of piRNA-mediated silencing of an invading transposable element was driven by abundant de novo mutations.Genome research · 2020Article
- Transposable elements inMobile DNA · 2020Review
- History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster.Frontiers in genetics · 2014Review
- The piRNA pathway in flies: highlights and future directions.Current opinion in genetics & development · 2013Review
- HP1 recruitment in the absence of argonaute proteins in Drosophila.PLoS genetics · 2010Article
- Polymorphism of canonical and noncanonical gypsy sequences in different species of Drosophila melanogaster subgroup: possible evolutionary relations.Molecular genetics and genomics : MGG · 2008Article
- Article
- The flamenco locus controls the gypsy and ZAM retroviruses and is required for Drosophila oogenesis.Genetics · 2007Article
- A novel repeat-associated small interfering RNA-mediated silencing pathway downregulates complementary sense gypsy transcripts in somatic cells of the Drosophila ovary.Journal of virology · 2007Article
- Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome.Genome biology · 2006Article
- Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline.Nucleic acids research · 2005Article
- Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene.Genetics · 2004Article
- COM, a heterochromatic locus governing the control of independent endogenous retroviruses from Drosophila melanogaster.Genetics · 2003Article
- Comparative and functional studies of Drosophila species invasion by the gypsy endogenous retrovirus.Genetics · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The flamenco gene, located at 20A1-3 in the beta-heterochromatin of the Drosophila X chromosome, is a major regulator of the gypsy/mdg4 endogenous retrovirus. As a first step to characterize this gene, approximately 100 kb of genomic DNA flanking a P-element-induced mutation of flamenco was isolated. This DNA is located in a sequencing gap of the Celera Genomics project, i.e., one of those parts of the genome in which the "shotgun" sequence could not be assembled, probably because it contains long stretches of repetitive DNA, especially on the proximal side of the P insertion point. Deficiency mapping indicated that sequences required for the normal flamenco function are located >130 kb proximal to the insertion site. The distal part of the cloned DNA does, nevertheless, contain several unique sequences, including at least four different transcription units. Dip1, the closest one to the P-element insertion point, might be a good candidate for a gypsy regulator, since it putatively encodes a nuclear protein containing two double-stranded RNA-binding domains. However, transgenes containing dip1 genomic DNA were not able to rescue flamenco mutant flies. The possible nature of the missing flamenco sequences is discussed.
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