ArticleGenetics2001
Regions of lower crossing over harbor more rare variants in African populations of Drosophila melanogaster.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Causal inference clarifies the roles of background selection and mutation rate variation in shaping human genetic diversity.bioRxiv : the preprint server for biology · 2026Article
- A model for background selection in non-equilibrium populations.bioRxiv : the preprint server for biology · 2025Article
- The evolutionary maintenance of ancient recombining sex chromosomes in the ostrich.PLoS genetics · 2023Article
- Gene flow as a simple cause for an excess of high-frequency-derived alleles.Evolutionary applications · 2020Article
- From molecules to populations: appreciating and estimating recombination rate variation.Nature reviews. Genetics · 2020Review
- Article
- Genomic signatures of domestication on neurogenetic genes in Drosophila melanogaster.BMC evolutionary biology · 2016Article
- On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity.Molecular ecology · 2016Article
- Characterizing neutral genomic diversity and selection signatures in indigenous populations of Moroccan goats (Capra hircus) using WGS data.Frontiers in genetics · 2015Article
- Effective population size does not predict codon usage bias in mammals.Ecology and evolution · 2014Article
- Joint assembly and genetic mapping of the Atlantic horseshoe crab genome reveals ancient whole genome duplication.GigaScience · 2014Article
- Genome differentiation of Drosophila melanogaster from a microclimate contrast in Evolution Canyon, Israel.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Genomic signatures of selection at linked sites: unifying the disparity among species.Nature reviews. Genetics · 2013Review
- Article
- The effect of variable frequency of sexual reproduction on the genetic structure of natural populations of a cyclical parthenogen.Evolution; international journal of organic evolution · 2012Article
- The Drosophila melanogaster Genetic Reference Panel.Nature · 2012Article
- Review
- Population Genomics of sub-saharan Drosophila melanogaster: African diversity and non-African admixture.PLoS genetics · 2012Article
- Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.PLoS genetics · 2011Article
- Article
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Authors and funding
2 authors.
Funding
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Abstract
A correlation between diversity levels and rates of recombination is predicted both by models of positive selection, such as hitchhiking associated with the rapid fixation of advantageous mutations, and by models of purifying selection against strongly deleterious mutations (commonly referred to as "background selection"). With parameter values appropriate for Drosophila populations, only the first class of models predicts a marked skew in the frequency spectrum of linked neutral variants, relative to a neutral model. Here, we consider 29 loci scattered throughout the Drosophila melanogaster genome. We show that, in African populations, a summary of the frequency spectrum of polymorphic mutations is positively correlated with the meiotic rate of crossing over. This pattern is demonstrated to be unlikely under a model of background selection. Models of weakly deleterious selection are not expected to produce both the observed correlation and the extent to which nucleotide diversity is reduced in regions of low (but nonzero) recombination. Thus, of existing models, hitchhiking due to the recurrent fixation of advantageous variants is the most plausible explanation for the data.
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