ArticleJournal of clinical immunology2001
Human mast cell apoptosis is regulated through Bcl-2 and Bcl-XL.
Article in Journal of clinical immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Evolution of mast cell research associated with the Laboratory of Allergic Diseases, 1985-2022: Summary of the 2023 NIAID Symposium.The Journal of allergy and clinical immunology · 2025Review
- A Critical Function for the Transcription Factors GLI1 and GLI2 in the Proliferation and Survival of Human Mast Cells.Frontiers in immunology · 2022Article
- Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs.Frontiers in immunology · 2022Review
- Detrimental effects of simulated microgravity on mast cell homeostasis and function.Frontiers in immunology · 2022Article
- Increased Platelet-CD4Frontiers in immunology · 2021Article
- Structural characterization and anticancer potency of centipede oligopeptides in human chondrosarcoma cancer: inducing apoptosis.RSC advances · 2020Article
- CD161mBio · 2019Article
- Article
- A subset of virus-specific CD161Blood · 2017Article
- Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models.Oncotarget · 2016Article
- IL-33/ST2 axis promotes mast cell survival via BCLXL.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Mast cell homeostasis and the JAK-STAT pathway.Genes and immunity · 2010Review
- Endogenous suppression of mast cell development and survival by IL-4 and IL-10.Journal of leukocyte biology · 2009Article
- Development, migration, and survival of mast cells.Immunologic research · 2006Review
- Article
- Expression of Bcl-2 and Bcl-xL in cutaneous and bone marrow lesions of mastocytosis.The American journal of pathology · 2003Article
- Mastocytosis and disorders of mast cell proliferation.Clinical reviews in allergy & immunology · 2002Review
- Mast cell growth, differentiation, and death.Clinical reviews in allergy & immunology · 2002Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
It is well established that human mast cell proliferation and maturation are regulated by kit ligand (stem cell factor). Little is known, however, about how these two processes are negatively regulated and thus, how mast cell number is controlled in normal and pathologic conditions. We therefore first hypothesized that SCF-dependent human mast cells would undergo programmed cell death (apoptosis) on removal of SCF as has been shown for growth factor-dependent rodent mast cells. We then examined whether SCF acts as a survival factor through the regulation of the bcl-2 family of apoptosis-regulatory genes. As hypothesized, elimination of SCF from primary peripheral blood-derived human mast cell cultures resulted in a significant apoptotic process. During apoptosis, down-regulation of the two apoptosis-regulatory proteins Bcl-2 and Bcl-XL was observed. Moreover, a deregulated expression of these two proteins was found in two human mast cell lines which are SCF-independent. Thus, SCF functions as a survival factor by repressing apoptosis of human mast cells through Bcl-2 and Bcl-XL. Deregulated expression of these antiapoptotic proteins may contribute to proliferation and accumulation of mast cells in certain forms of systemic mast cell disorders.
Indexed as
Identifiers
11403223What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.