ArticleOncogene2001
In vitro and in vivo inhibition of epidermal growth factor receptor-tyrosine kinase pathway by photodynamic therapy.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- Photoimmunotherapy of Ovarian Cancer: A Unique Niche in the Management of Advanced Disease.Cancers · 2019Review
- Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity.International journal of molecular sciences · 2016Article
- Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy.Oncogene · 2015Article
- Nimotuzumab increases the anti-tumor effect of photodynamic therapy in an oral tumor model.Oncotarget · 2015Article
- Apoptotic effects of Photofrin-Diomed 630-PDT on SHEEC human esophageal squamous cancer cells.International journal of clinical and experimental medicine · 2015Article
- Cellular intrinsic factors involved in the resistance of squamous cell carcinoma to photodynamic therapy.The Journal of investigative dermatology · 2014Article
- Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways.International journal of clinical and experimental pathology · 2014Article
- Photodynamic therapy with 3-(1'-hexyloxyethyl) pyropheophorbide a for cancer of the oral cavity.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- A new nanoconstruct for epidermal growth factor receptor-targeted photo-immunotherapy of ovarian cancer.Nanomedicine : nanotechnology, biology, and medicine · 2013Article
- GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy.Cell death & disease · 2013Article
- The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells.Lasers in medical science · 2013Article
- Photodynamic therapy activated signaling from epidermal growth factor receptor and STAT3: Targeting survival pathways to increase PDT efficacy in ovarian and lung cancer.Cancer biology & therapy · 2012Article
- Photoimmunotherapy and irradiance modulation reduce chemotherapy cycles and toxicity in a murine model for ovarian carcinomatosis: perspective and results.Israel journal of chemistry · 2012Article
- Photodynamic therapy-induced angiogenic signaling: consequences and solutions to improve therapeutic response.Israel journal of chemistry · 2012Article
- Epidermal growth factor receptor-targeted photosensitizer selectively inhibits EGFR signaling and induces targeted phototoxicity in ovarian cancer cells.Cancer letters · 2012Article
- The role of epidermal growth factor receptor in photodynamic therapy: a review of the literature and proposal for future investigation.Lasers in medical science · 2010Review
- Targeted Therapy of Cancer Using Photodynamic Therapy in Combination with Multi-faceted Anti-Tumor Modalities.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response.Molecular cancer · 2009Article
- Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death.Photodiagnosis and photodynamic therapy · 2005Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
PDT, a new therapeutic procedure for the management of many malignant conditions including skin cancer, involves the administration of a photosensitizing compound followed by illumination of the lesion with visible light. We earlier showed an involvement of: (i) WAF1/p21-cyclins (D1 and E)-cdk (2 and 6) network; and (ii) Rb/E2F-DP machinery during silicon phthalocyanine (Pc4)-PDT-mediated cell cycle dysregulation and apoptosis of human epidermoid carcinoma (A431) cells. Here, we investigated the involvement of EGFR-pathway during antiproliferative responses of Pc4-PDT in A431 cells and during ablation of murine skin papillomas. Pc4-PDT of A431 cells was found to result in a time-dependent down-modulation of the protein expression and phosphorylation of EGFR and Shc (an immediate downstream molecule in EGFR-pathway), during progressive increase in apoptotic response. To establish the relevance of these in vitro findings to in vivo situations, we subjected chemically- as well as ultraviolet B radiation-induced squamous papillomas in SENCAR and SKH-1 hairless mice, respectively, to Pc4-PDT, and assessed its effect on EGFR-pathway during ablation of these tumors. Pc4-PDT was found to result in a time-dependent: (i) inhibition of protein expressions of EGFR; and (ii) tyrosine phosphorylation of EGFR and Shc; and (iii) induction of apoptosis, during the regression of these tumors. These data suggest the involvement of EGFR-pathway during the antiproliferative effects of PDT. It is tempting to speculate that inhibitors of EGFR could enhance the therapeutic efficacy of PDT.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.