ArticleOncogene2001
Expression of ring finger-deleted TRAF2 sensitizes metastatic melanoma cells to apoptosis via up-regulation of p38, TNFalpha and suppression of NF-kappaB activities.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Review
- Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10.Oxidative medicine and cellular longevity · 2022Article
- Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways.Oncotarget · 2017Article
- Cell fate regulated by nuclear factor-κB- and activator protein-1-dependent signalling in human melanocytes exposed to ultraviolet A and ultraviolet B.The British journal of dermatology · 2014Article
- UVB-stimulated TNFα release from human melanocyte and melanoma cells is mediated by p38 MAPK.International journal of molecular sciences · 2013Article
- ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα.Cell death & disease · 2013Article
- Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways.Pigment cell & melanoma research · 2011Article
- Effect of novel marine nutraceuticals on IL-1α-mediated TNF-α release from UVB-irradiated human melanocyte-derived cells.Oxidative medicine and cellular longevity · 2011Article
- Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.Cancer research · 2008Article
- Preclinical studies of celastrol and acetyl isogambogic acid in melanoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2007Article
- Article
- Up-regulation of Fas (CD95) expression in tumour cells in vivo.Immunology · 2007Article
- Herpesvirus saimiri STP-A oncoprotein utilizes Src family protein tyrosine kinase and tumor necrosis factor receptor-associated factors to elicit cellular signal transduction.Journal of virology · 2007Article
- Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells.Experimental cell research · 2006Article
- Role of nuclear factor-kappa B in melanoma.Cancer metastasis reviews · 2005Review
- Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathway.The Journal of biological chemistry · 2004Article
- TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLF.Molecular and cellular biology · 2003Article
- Death receptors and melanoma resistance to apoptosis.Oncogene · 2003Review
- Apoptosis and melanoma chemoresistance.Oncogene · 2003Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Mechanisms underlying radiation and chemotherapy resistance, the hallmark of human melanoma, are not well understood. Here we demonstrate that expression levels of signal adaptor protein TRAF2 coincide with melanoma resistance to UV-irradiation. Altered TRAF2 signaling by a form of TRAF2, which lacks the ring finger domain (TRAF2DeltaN), increases activities of p38 MAPK, ATF2, and the level of TNFalpha expression. Forced expression of TRAF2DeltaN in HHMSX highly metastatic melanoma cells that lack Fas expression and thus utilize the TNFalpha-TNFR1 as the major apoptotic pathway sensitized cells to UV-induced apoptosis. An over twofold increase in degree of apoptosis was observed in TRAF2DeltaN expressing cells that were treated with actinomycin D, anisomycin or with the radiomimetic drug neocarzinostatin. Sensitization by TRAF2DeltaN is selective since it was not observed in response to either Taxol or cis-platinum treatment. TRAF2DeltaN effects are primarily mediated via p38 since inhibition of p38 reduces, whereas activation of p38 promotes the level of UV-induced apoptosis. Conversely, activation of IKK attenuates the sensitization of melanoma by TRAF2DeltaN, indicating that p38-mediated suppression of NF-kappaB activity is among TRAF2DeltaN effects. Our finding identifies p38, TNFalpha and NF-kappaB among key players that efficiently sensitizes melanoma cells to UV-, ribotoxic (anisomycin) and radiomimetic chemicals-induced programmed cell death in response to aberrant TRAF2 signaling.
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