ArticlePlant physiology2001
The Rop GTPase switch controls multiple developmental processes in Arabidopsis.
Article in Plant physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 218 citations in OpenAlex.
- Active ROP2 triggers leaf senescence and orchestrates the growth-senescence trade-off under nitrogen starvation.Plant signaling & behavior · 2026Article
- Growth history leaves a geometric trace in puzzle cells.EMBO reports · 2026Article
- Independent roles of Arp2/3 complex and RIC4 protein in the control of epidermal cell shape.Planta · 2026Article
- Rho GTPase overexpression impacts leaf internal architecture and mesophyll conductance in Arabidopsis.The New phytologist · 2025Article
- The REPLUMLESS Transcription Factor Controls the Expression of theInternational journal of molecular sciences · 2024Article
- RHO OF PLANTS signalling and the activating ROP GUANINE NUCLEOTIDE EXCHANGE FACTORS: specificity in cellular signal transduction in plants.Journal of experimental botany · 2024Review
- Cloning and Functional Analysis of CsROP5 and CsROP10 Genes Involved in Cucumber Resistance toBiology · 2024Article
- Metabolic regulation of quiescence in plants.The Plant journal : for cell and molecular biology · 2023Article
- Analysis of Rac/Rop Small GTPase Family Expression inLife (Basel, Switzerland) · 2022Article
- ROP signaling regulates spatial pattern of cell division and specification of meristem notch.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genome-Wide Identification of Genes Encoding for Rho-Related Proteins in 'Plants (Basel, Switzerland) · 2022Article
- A Small Gtp-Binding Protein GhROP3 Interacts with GhGGB Protein and Negatively Regulates Drought Tolerance in Cotton (Plants (Basel, Switzerland) · 2022Article
- Division site determination during asymmetric cell division in plants.The Plant cell · 2022Review
- Calmodulin Domain Protein Kinase PiCDPK1 Regulates Pollen Tube Growth Polarity through Interaction with RhoGDI.Plants (Basel, Switzerland) · 2022Article
- Genome-wide association and RNA-seq analyses identify loci for pod orientation in rapeseed (Frontiers in plant science · 2022Article
- Nuclear export of plant pararetrovirus mRNAs involves the TREX complex, two viral proteins and the highly structured 5' leader region.Nucleic acids research · 2021Article
- Cell polarity: Regulators and mechanisms in plants.Journal of integrative plant biology · 2020Review
- MYB96 recruits the HDA15 protein to suppress negative regulators of ABA signaling in Arabidopsis.Nature communications · 2019Article
- Rho-of-plant activated root hair formation requiresDevelopment (Cambridge, England) · 2019Article
- Overexpression of a NovelInternational journal of molecular sciences · 2018Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G proteins are universal molecular switches in eukaryotic signal transduction. The Arabidopsis genome sequence reveals no RAS small GTPase and only one or a few heterotrimeric G proteins, two predominant classes of signaling G proteins found in animals. In contrast, Arabidopsis possesses a unique family of 11 Rop GTPases that belong to the Rho family of small GTPases. Previous studies indicate that Rop controls actin-dependent pollen tube growth and H(2)O(2)-dependent defense responses. In this study, we tested the hypothesis that the Rop GTPase acts as a versatile molecular switch in signaling to multiple developmental processes in Arabidopsis. Immunolocalization using a general antibody against the Rop family proteins revealed a ubiquitous distribution of Rop proteins in all vegetative and reproductive tissues and cells in Arabidopsis. The cauliflower mosaic virus 35S promoter-directed expression of constitutively active GTP-bound rop2 (CA-rop2) and dominant negative GDP-bound rop2 (DN-rop2) mutant genes impacted many aspects of plant growth and development, including embryo development, seed dormancy, seedling development, lateral root initiation, morphogenesis of lateral organs in the shoot, shoot apical dominance and growth, phyllotaxis, and lateral organ orientation. The rop2 transgenic plants also displayed altered responses to the exogenous application of several hormones, such as abscisic acid-mediated seed dormancy, auxin-dependent lateral shoot initiation, and brassinolide-mediated hypocotyl elongation. CA-rop2 and DN-rop2 expression had opposite effects on most of the affected processes, supporting a direct signaling role for Rop in regulating these processes. Based on these observations and previous results, we propose that Rop2 and other members of the Rop family participate in multiple distinct signaling pathways that control plant growth, development, and responses to the environment.
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