ArticlePlant physiology2001
The heme-oxygenase family required for phytochrome chromophore biosynthesis is necessary for proper photomorphogenesis in higher plants.
Article in Plant physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 141 citations in OpenAlex.
- TheCurrent issues in molecular biology · 2026Article
- Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis.eLife · 2024Article
- Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis.bioRxiv : the preprint server for biology · 2024Article
- Thai Oakleaf Lettuce Phenocopies a Phytochrome B Mutant.Biology · 2024Article
- Enzymological and structural characterization of Arabidopsis thaliana heme oxygenase-1.FEBS open bio · 2022Article
- Protection Against Post-resuscitation Acute Kidney Injury by N-Acetylcysteine via Activation of the Nrf2/HO-1 Pathway.Frontiers in medicine · 2022Article
- High-resolution imaging as a tool for identifying quantitative trait loci that regulate photomorphogenesis inAoB PLANTS · 2021Article
- Fungal phytochrome chromophore biosynthesis at mitochondria.The EMBO journal · 2021Article
- Article
- Immune Modulation by Inhibitors of the HO System.International journal of molecular sciences · 2020Review
- Article
- Is there a role for tau glutathione transferases in tetrapyrrole metabolism and retrograde signalling in plants?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Characterization and Expression Analysis of Heme Oxygenase Genes fromBioinformatics and biology insights · 2019Article
- Roles and maturation of iron-sulfur proteins in plastids.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Review
- Article
- Light Controls Cytokinin Signaling via Transcriptional Regulation of Constitutively Active Sensor Histidine Kinase CKI1.Plant physiology · 2017Article
- Heme oxygenase 1 defects lead to reduced chlorophyll in Brassica napus.Plant molecular biology · 2017Article
- Transcriptional Orchestration of the Global Cellular Response of a Model Pennate Diatom to Diel Light Cycling under Iron Limitation.PLoS genetics · 2016Article
- In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis.Biochemistry · 2016Article
- The effects of phytochrome-mediated light signals on the developmental acquisition of photoperiod sensitivity in rice.Scientific reports · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The committed step in the biosynthesis of the phytochrome chromophore phytochromobilin involves the oxidative cleavage of heme by a heme oxygenase (HO) to form biliverdin IXalpha. Through positional cloning of the photomorphogenic mutant hy1, the Arabidopsis HO (designated AtHO1) responsible for much of phytochromobilin synthesis recently was identified. Using the AtHO1 sequence, we identified families of HO genes in a number of plants that cluster into two subfamilies (HO1- and HO2-like). The tomato (Lycopersicon esculentum) yg-2 and Nicotiana plumbaginifolia pew1 photomorphogenic mutants are defective in specific HO genes. Phenotypic analysis of a T-DNA insertion mutant of Arabidopsis HO2 revealed that the second HO subfamily also contributes to phytochromobilin synthesis. Homozygous ho2-1 plants show decreased chlorophyll accumulation, reduced growth rate, accelerated flowering time, and reduced de-etiolation. A mixture of apo- and holo-phyA was detected in etiolated ho2-1 seedlings, suggesting that phytochromobilin is limiting in this mutant, even in the presence of functional AtHO1. The patterns of Arabidopsis HO1 and HO2 expression suggest that the products of both genes overlap temporally and spatially. Taken together, the family of HOs is important for phytochrome-mediated development in a number of plants and that each family member may uniquely contribute to the phytochromobilin pool needed to assemble holo-phytochromes.
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