ArticleInfection and immunity2001
Endogenous interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitis.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study.Journal of translational medicine · 2020Article
- Characterization of a Listeria monocytogenes meningitis mouse model.Journal of neuroinflammation · 2018Article
- Invasion of the Brain bymBio · 2018Article
- Complexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis.Journal of immunology research · 2015Review
- IL-10 deficiency exacerbates the brain inflammatory response to permanent ischemia without preventing resolution of the lesion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Soluble ST2 in the fetal inflammatory response syndrome: in vivo evidence of activation of the anti-inflammatory limb of the immune response.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2013Article
- CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production.PLoS pathogens · 2013Article
- Regulation of adaptive immunity; the role of interleukin-10.Frontiers in immunology · 2013Article
- Article
- Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Modulation of immune response by interleukin-10 in systemic Corynebacterium kutscheri infection in mice.Journal of microbiology (Seoul, Korea) · 2012Article
- The behaviour of both Listeria monocytogenes and rat ciliated ependymal cells is altered during their co-culture.PloS one · 2010Article
- IL-10 production by CD4+ effector T cells: a mechanism for self-regulation.Mucosal immunology · 2010Review
- Rhombencephalitis Caused by Listeria monocytogenes in Humans and Ruminants: A Zoonosis on the Rise?Interdisciplinary perspectives on infectious diseases · 2010Article
- IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Interleukin 10 protects the brain microcirculation from spirochetal injury.Journal of neuropathology and experimental neurology · 2008Article
- IL-10 helps control pathogen load during high-level bacteremia.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: a role for interleukin-10.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2008Article
- Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia.Neurobiology of disease · 2007Article
- Genetically attenuated Plasmodium berghei liver stages persist and elicit sterile protection primarily via CD8 T cells.The American journal of pathology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To analyze the role of interleukin-10 (IL-10) in bacterial cerebral infections, we studied cerebral listeriosis in IL-10-deficient (IL-10(-/-)) and wild-type (WT) mice, the latter of which express high levels of IL-10 in both primary and secondary cerebral listeriosis. IL-10(-/-) mice succumbed to primary as well as secondary listeriosis, whereas WT mice were significantly protected from secondary listeriosis by prior intraperitoneal immunization with Listeria monocytogenes. Meningoencephalitis developed in both strains; however, in IL-10(-/-) mice the inflammation was more severe and associated with increased brain edema and multiple intracerebral hemorrhages. IL-10(-/-) mice recruited significantly increased numbers of leukocytes, in particular granulocytes, to the brain, and the intracerebral cytokine (tumor necrosis factor, IL-1, IL-12, gamma interferon, and inducible nitric oxide synthase) and chemokine (crg2/IP-10, RANTES, MuMig, macrophage inflammatory protein 1alpha [MIP-1alpha], and MIP-1beta) transcription was enhanced compared to that in WT mice. Despite this prominent hyperinflammation, the frequencies of intracerebral L. monocytogenes-specific CD8(+) T cells were reduced and the intracerebral bacterial load was not reduced in IL-10(-/-) mice compared to WT mice. Following intraperitoneal infection, IL-10(-/-) mice exhibited hepatic hyperinflammation without better bacterial clearance; however, in contrast to the mice with cerebral listeriosis, they did not succumb, illustrating that intrinsic factors of the target organ have a strong impact on the course and outcome of the infection.
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