ArticleInfection and immunity2001
Dendritic cell activation and cytokine production induced by group B Neisseria meningitidis: interleukin-12 production depends on lipopolysaccharide expression in intact bacteria.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- NicheProt: Cell-type-resolved proteomics of tissue compartments.Science advances · 2026Article
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- Kinetic Changes in B7 Costimulatory Molecules and IRF4 Expression in Human Dendritic Cells during LPS Exposure.Biomolecules · 2022Article
- Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α.Science translational medicine · 2018Article
- PKCδ-Mediated Nox2 Activation Promotes Fluid-Phase Pinocytosis of Antigens by Immature Dendritic Cells.Frontiers in immunology · 2018Article
- Meningococcal Outer Membrane Vesicle Composition-Dependent Activation of the Innate Immune Response.Infection and immunity · 2016Article
- IL12Rβ1: the cytokine receptor that we used to know.Cytokine · 2015Review
- Article
- LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A.Cellular microbiology · 2014Article
- Periodontal disease immunology: 'double indemnity' in protecting the host.Periodontology 2000 · 2013Review
- Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection.PloS one · 2010Article
- Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis.Infection and immunity · 2008Article
- Fate of a Burkholderia pseudomallei lipopolysaccharide mutant in the mouse macrophage cell line RAW 264.7: possible role for the O-antigenic polysaccharide moiety of lipopolysaccharide in internalization and intracellular survival.Infection and immunity · 2007Article
- Regulation of murine dendritic cell immune responses by Helicobacter felis antigen.Infection and immunity · 2006Article
- MyD88-dependent signaling affects the development of meningococcal sepsis by nonlipooligosaccharide ligands.Infection and immunity · 2006Article
- The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses.The Journal of clinical investigation · 2006Article
- Impact of Helicobacter pylori virulence factors and compounds on activation and maturation of human dendritic cells.Infection and immunity · 2005Article
- Induction of maturation and cytokine release of human dendritic cells by Helicobacter pylori.Infection and immunity · 2004Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions between dendritic cells (DCs) and microbial pathogens are fundamental to the generation of innate and adaptive immune responses. Upon stimulation with bacteria or bacterial components such as lipopolysaccharide (LPS), immature DCs undergo a maturation process that involves expression of costimulatory molecules, HLA molecules, and cytokines and chemokines, thus providing critical signals for lymphocyte development and differentiation. In this study, we investigated the response of in vitro-generated human DCs to a serogroup B strain of Neisseria meningitidis compared to an isogenic mutant lpxA strain totally deficient in LPS and purified LPS from the same strain. We show that the parent strain, lpxA mutant, and meningococcal LPS all induce DC maturation as measured by increased surface expression of costimulatory molecules and HLA class I and II molecules. Both the parent and lpxA strains induced production of tumor necrosis factor alpha (TNF-alpha), interleukin-1alpha (IL-1alpha), and IL-6 in DCs, although the parent was the more potent stimulus. In contrast, high-level IL-12 production was only seen with the parent strain. Compared to intact bacteria, purified LPS was a very poor inducer of IL-1alpha, IL-6, and TNF-alpha production and induced no detectable IL-12. Addition of exogenous LPS to the lpxA strain only partially restored cytokine production and did not restore IL-12 production. These data show that non-LPS components of N. meningitidis induce DC maturation, but that LPS in the context of the intact bacterium is required for high-level cytokine production, especially that of IL-12. These findings may be useful in assessing components of N. meningitidis as potential vaccine candidates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.