ArticleInfection and immunity2001
Polysaccharide biosynthesis locus required for virulence of Bacteroides fragilis.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 102 citations in OpenAlex.
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- Phylogenomics and Antimicrobial Resistance of ClinicalAntibiotics (Basel, Switzerland) · 2025Article
- The Ambivalent Nature ofToxins · 2025Review
- Bacteroides expand the functional versatility of a conserved transcription factor and transcribed DNA to program capsule diversity.Nature communications · 2024Article
- PathogenicbioRxiv : the preprint server for biology · 2024Article
- Gut commensals require Peyer's patches to induce protective systemic IgA responses.Research square · 2024Article
- Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota.Cell host & microbe · 2024Article
- Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity.Science advances · 2023Article
- Chemical Reporters for Bacterial Glycans: Development and Applications.Chemical reviews · 2022Review
- Profiling of Intestinal Microbiota in Patients Infected with Respiratory Influenza A and B Viruses.Pathogens (Basel, Switzerland) · 2021Article
- Strain diversity in the microbiome: Lessons from Bacteroides fragilis.PLoS pathogens · 2020Review
- Intestinal microbes influence development of thymic lymphocytes in early life.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Pyruvate Substitutions on Glycoconjugates.International journal of molecular sciences · 2019Review
- Polysaccharide A-Dependent Opposing Effects of Mucosal and Systemic Exposures to Human Gut CommensalDiabetes · 2019Article
- Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A.Mucosal immunology · 2019Article
- The Protective Role ofmSphere · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Bacteroides fragilis, though only a minor component of the human intestinal commensal flora, is the anaerobe most frequently isolated from intra-abdominal abscesses. B. fragilis 9343 expresses at least three capsular polysaccharides-polysaccharide A (PS A), PS B, and PS C. Purified PS A and PS B have been tested in animal models and are both able to induce the formation of intra-abdominal abscesses. Mutants unable to synthesize PS B or PS C still facilitate abscess formation at levels comparable to those of wild-type 9343. To determine the contribution of PS A to abscess formation in the context of the intact organism, the PS A biosynthesis region was cloned, sequenced, and deleted from 9343 to produce a PS A-negative mutant. Animal experiments demonstrate that the abscess-inducing capability of 9343 is severely attenuated when the organism cannot synthesize PS A, despite continued synthesis of the other capsular polysaccharides. The PS A of 9343 contains an unusual free amino sugar that is essential for abscess formation by this polymer. PCR analysis of the PS A biosynthesis loci of 50 B. fragilis isolates indicates that regions flanking each side of this locus are conserved in all strains. The downstream conserved region includes two terminal PS A biosynthesis genes that homology-based analyses predict are involved in the synthesis and transfer of the free amino sugar of PS A. Conservation of these genes suggests that this sugar is present in the PS A of all serotypes and may explain the abscessogenic nature of B. fragilis.
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