ArticleAmerican journal of physiology. Cell physiology2001
ANG II-mediated inhibition of neuronal delayed rectifier K+ current: role of protein kinase C-alpha.
Article in American journal of physiology. Cell physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 27 citations in OpenAlex.
- Calcium/Calmodulin-Dependent Kinases in the Hypothalamus, Pituitary, and Pineal Gland: An Overview.International journal of endocrinology · 2022Review
- BDNF contributes to angiotensin II-mediated reductions in peak voltage-gated K+ current in cultured CATH.a cells.Physiological reports · 2015Article
- Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology.Biophysical journal · 2015Article
- Article
- Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium current.American journal of physiology. Cell physiology · 2010Article
- Excitatory roles of protein kinase C in striatal cholinergic interneurons.Journal of neurophysiology · 2009Article
- Area-specific differences in transmitter release in central catecholaminergic neurons of spontaneously hypertensive rats.Hypertension (Dallas, Tex. : 1979) · 2008Article
- The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons.Neuroscience · 2008Article
- Involvement of Src tyrosine kinase and mitogen-activated protein kinase in the facilitation of calcium channels in rat nucleus of the tractus solitarius by angiotensin II.The Journal of physiology · 2005Article
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5 authors at 1 institution in 1 country.
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Abstract
It was previously determined that ANG II and phorbol esters inhibit Kv current in neurons cultured from newborn rat hypothalamus and brain stem in a protein kinase C (PKC)- and Ca2+-dependent manner. Here, we have further defined this signaling pathway by investigating the roles of "physiological" activators of PKC and different PKC isozymes. The cell-permeable PKC activators, diacylglycerol (DAG) analogs 1,2-dioctanoyl-sn-glycerol (1 micromol/l, n = 7) and 1-oleoyl-2-acetyl-sn-glycerol (1 micromol/l, n = 6), mimicked the effect of ANG II and inhibited Kv current. These effects were abolished by the PKC inhibitor chelerythrine (1 micromol/l, n = 5) or by chelation of internal Ca2+ (n = 8). PKC antisense (AS) oligodeoxynucleotides (2 micromol/l) against Ca2+-dependent PKC isoforms were applied to the neurons to manipulate the endogenous levels of PKC. PKC-alpha-AS (n = 4) treatment abolished the inhibitory effects of ANG II and 1-oleoyl-2-acetyl-sn-glycerol on Kv current, whereas PKC-beta-AS (n = 4) and PKC-gamma-AS (n = 4) did not. These results suggest that the angiotensin type 1 receptor-mediated effects of ANG II on neuronal Kv current involve activation of PKC-alpha.
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