ArticleEnvironmental health perspectives2001
Data quality in predictive toxicology: reproducibility of rodent carcinogenicity experiments.
Article in Environmental health perspectives, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens.Archives of toxicology · 2020Guideline
- Variability and uncertainty of data from genotoxicity test guidelines: what we know and why it matters.Archives of toxicology · 2026Review
- Article
- Perspectives on variability ofFrontiers in toxicology · 2026Article
- Reproducibility of organ-level effects in repeat dose animal studies.Computational toxicology (Amsterdam, Netherlands) · 2023Article
- An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis.Chemical research in toxicology · 2023Review
- Classifying polycyclic aromatic hydrocarbons by carcinogenic potency using in vitro biosignatures.Toxicology in vitro : an international journal published in association with BIBRA · 2020Article
- Structure-based QSAR Models to Predict Repeat Dose Toxicity Points of Departure.Computational toxicology (Amsterdam, Netherlands) · 2020Article
- Variability inComputational toxicology (Amsterdam, Netherlands) · 2020Article
- Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Predicting toxicity of chemicals: software beats animal testing.EFSA journal. European Food Safety Authority · 2019Article
- Article
- Reproducibility and Research Integrity.Accountability in research · 2017Article
- Paradigm shift in toxicity testing and modeling.The AAPS journal · 2012Review
- Mammary carcinogen-protein binding potentials: novel and biologically relevant structure-activity relationship model descriptors.SAR and QSAR in environmental research · 2010Article
- Toxicology for the twenty-first century.Nature · 2009Article
- Longer rodent bioassay fails to address 2-year bioassay's flaws.Environmental health perspectives · 2008Article
- Lazy structure-activity relationships (lazar) for the prediction of rodent carcinogenicity and Salmonella mutagenicity.Molecular diversity · 2006Article
- An expert-driven literature review of "negative" chemicals for developmental neurotoxicity (DNT) in vitro assay evaluation.Neurotoxicology and teratologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared 121 replicate rodent carcinogenicity assays from the two parts (National Cancer Institute/National Toxicology Program and literature) of the Carcinogenic Potency Database (CPDB) to estimate the reliability of these experiments. We estimated a concordance of 57% between the overall rodent carcinogenicity classifications from both sources. This value did not improve substantially when additional biologic information (species, sex, strain, target organs) was considered. These results indicate that rodent carcinogenicity assays are much less reproducible than previously expected, an effect that should be considered in the development of structure-activity relationship models and the risk assessment process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.