Evidence map›Paper›PMID 11395476›Full record

ArticleJournal of bacteriology2001

Characterization of Escherichia coli type 1 pilus mutants with altered binding specificities.

S L Harris, P A Spears, E A Havell, T S Hamrick, J R Horton, P E Orndorff

Abstract read
In one paragraph

Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Design and synthesis of theranostic antibiotic nanodrugs that display enhanced antibacterial activity and luminescence.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Maltoheptaose promotes nanoparticle internalization by Escherichia coli.Chemical communications (Cambridge, England) · 2013
    Article
  11. Article
  12. Dye-doped silica nanoparticles as efficient labels for glycans.Chemical communications (Cambridge, England) · 2011
    Article
  13. Quantitative glycomics from fluidic glycan microarrays.Journal of the American Chemical Society · 2009
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

S L HarrisDepartment of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA.
P A Spears
E A Havell
T S Hamrick
J R Horton
P E Orndorff

Funding

CONTROL AND EXPRESSION OF TYPE 1 PILI IN E. COLIR01AI022223 · NIAID · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI ORNDORFF, PAUL EDWIN · 1985 to 1999
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NIAID NIH HHS AI22223
6 · The paper itself

Abstract

PCR mutagenesis and a unique enrichment scheme were used to obtain two mutants, each with a single lesion in fimH, the chromosomal gene that encodes the adhesin protein (FimH) of Escherichia coli type 1 pili. These mutants were noteworthy in part because both were altered in the normal range of cell types bound by FimH. One mutation altered an amino acid at a site previously shown to be involved in temperature-dependent binding, and the other altered an amino acid lining the predicted FimH binding pocket.

Indexed as

Adhesins, Escherichia coliFimbriae ProteinsAdhesins, BacterialAllelesChromosomes, BacterialEscherichia coliFimbriae, BacterialMolecular Sequence DataMutationPhenotypePlasmidsRecombination, GeneticAdhesins, BacterialAdhesins, Escherichia coliFimbriae ProteinsfimH protein, E coli

Identifiers

PMID11395476
PMCPMC95295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.