ArticleJournal of bacteriology2001
Signaling system in Porphyromonas gingivalis based on a LuxS protein.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 141 citations in OpenAlex.
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- Hemin availability induces coordinated DNA methylation and gene expression changes inmSystems · 2023Article
- Candidate Phyla Radiation, an Underappreciated Division of the Human Microbiome, and Its Impact on Health and Disease.Clinical microbiology reviews · 2022Review
- Anti-biofilm activities of coumarin as quorum sensing inhibitor forJournal of oral microbiology · 2022Article
- A Novel Small Molecule, 1,3-di-m-tolyl-urea, Inhibits and Disrupts Multispecies Oral Biofilms.Microorganisms · 2020Article
- Probiotics alter biofilm formation and the transcription ofJournal of oral microbiology · 2020Article
- Article
- Amino acids as wetting agents: surface translocation by Porphyromonas gingivalis.The ISME journal · 2019Article
- Comparative gene expression analysis of planktonic Porphyromonas gingivalis ATCC 33277 in the presence of a growing biofilm versus planktonic cells.BMC microbiology · 2019Article
- Quorum Sensing Modulates the Epibiotic-Parasitic Relationship BetweenFrontiers in microbiology · 2018Article
- Survival of an Aggregatibacter actinomycetemcomitans quorum sensing luxS mutant in the mouths of Rhesus monkeys: insights into ecological adaptation.Molecular oral microbiology · 2017Article
- New approaches to combatJournal of oral microbiology · 2017Review
- Autoinducer-2 detection among commensal oral streptococci is dependent on pH and boric acid.Journal of microbiology (Seoul, Korea) · 2016Article
- Quorum Sensing of Periodontal Pathogens.Acta stomatologica Croatica · 2015Review
- DNA methylation differentially regulates cytokine secretion in gingival epithelia in response to bacterial challenges.Pathogens and disease · 2015Article
- Article
- Life in a Diverse Oral Community - Strategies for Oxidative Stress Survival.Journal of oral biosciences · 2014Article
- Intercellular communications in multispecies oral microbial communities.Frontiers in microbiology · 2014Review
- AI-2 of Aggregatibacter actinomycetemcomitans inhibits Candida albicans biofilm formation.Frontiers in cellular and infection microbiology · 2014Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The luxS gene of quorum-sensing Vibrio harveyi is required for type 2 autoinducer production. We identified a Porphyromonas gingivalis open reading frame encoding a predicted peptide of 161 aa that shares 29% identity with the amino acid sequence of the LuxS protein of V. harveyi. Conditioned medium from a late-log-phase P. gingivalis culture induced the luciferase operon of V. harveyi, but that from a luxS insertional mutant did not. In P. gingivalis, the expression of luxS mRNA was environmentally controlled and varied according to the cell density and the osmolarity of the culture medium. In addition, differential display PCR showed that the inactivation of P. gingivalis luxS resulted in up-regulation of a hemin acquisition protein and an arginine-specific protease and reduced expression of a hemin-regulated protein, a TonB homologue, and an excinuclease. The data suggest that the luxS gene in P. gingivalis may function to control the expression of genes involved in the acquisition of hemin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.