ArticleJournal of bacteriology2001
Promoters of the CATG-specific methyltransferase gene hpyIM differ between iceA1 and iceA2 Helicobacter pylori strains.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Global epidemiology ofMicrobiology spectrum · 2026Article
- Prevalence of Helicobacter pylori genotypes: cagA, vacA (m1), vacA (s1), babA2, dupA, iceA1, oipA and their association with gastrointestinal diseases. A cross-sectional study in Quito-Ecuador.BMC gastroenterology · 2023Article
- Outer Membrane Vesicles (OMVs) as Biomedical Tools and Their Relevance as Immune-Modulating Agents againstInternational journal of molecular sciences · 2023Review
- Review
- High correlation of babA 2-positive strains of Helicobacter pylori with the presence of gastric cancer.Internal and emergency medicine · 2013Article
- Natural transformation of an engineered Helicobacter pylori strain deficient in type II restriction endonucleases.Journal of bacteriology · 2012Article
- Molecular Basis of pathogenicity in Helicobacter pylori clinical isolates.Journal of clinical microbiology · 2010Article
- Clinical significance of Helicobacter pylori cagA and iceA genotype status.World journal of gastroenterology · 2010Article
- Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration.BMC microbiology · 2009Article
- The 3'-to-5' exoribonuclease (encoded by HP1248) of Helicobacter pylori regulates motility and apoptosis-inducing genes.Journal of bacteriology · 2009Article
- Comparative genomics of Helicobacter pylori isolates recovered from ulcer disease patients in England.BMC microbiology · 2005Article
- Helicobacter pylori interstrain restriction-modification diversity prevents genome subversion by chromosomal DNA from competing strains.Nucleic acids research · 2002Article
- Functional analysis of iceA1, a CATG-recognizing restriction endonuclease gene in Helicobacter pylori.Nucleic acids research · 2002Article
- Virulence genes in Helicobacter pylori strains from West Bengal residents with overt H. pylori-associated disease and healthy volunteers.Journal of clinical microbiology · 2002Article
- Phenotypic and genotypic variation in methylases involved in type II restriction-modification systems in Helicobacter pylori.Nucleic acids research · 2002Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Helicobacter pylori strains can be divided into two groups, based on the presence of two unrelated genes, iceA1 and iceA2, that occupy the same genomic locus. hpyIM, located immediately downstream of either gene, encodes a functional CATG-specific methyltransferase. Despite the strong conservation of the hpyIM open reading frame (ORF) among all H. pylori strains, the sequences upstream of the ORF in iceA1 and iceA2 strains are substantially different. To explore the roles of these upstream sequences in hpyIM regulation, promoter analysis of hpyIM was performed. Both deletion mutation and primer extension analyses demonstrate that the hpyIM promoters differ between H. pylori strains 60190 (iceA1) and J188 (iceA2). In strain 60190, hpyIM has two promoters, P(a) or P(I), which may function independently, whereas only one hpyIM promoter, P(c), was found in strain J188. The XylE assay showed that the hpyIM transcription level was much higher in strain 60190 than in strain J188, indicating that regulation of hpyIM transcription differs between the H. pylori iceA1 strain (60190) and iceA2 strains (J188). Since the iceA1 and iceA2 sequences are highly conserved within iceA1 or iceA2 strains, we conclude that promoters of the CATG-specific methylase gene hpyIM differ between iceA1 and iceA2 strains, which leads to differences in regulation of hpyIM transcription.
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