ArticleThe American journal of pathology2001
Time course of endothelial cell proliferation and microvascular remodeling in chronic inflammation.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 128 citations in OpenAlex.
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- Identification of venular capillary remodelling: a possible link to the development of periodontitis?Journal of periodontal & implant science · 2022Article
- Sequential and Dynamic Variations of IL-6, CD18, ICAM, TNF-Disease markers · 2022Article
- Peptide-targeted liposomal delivery of dexamethasone for arthritis therapy.Nanomedicine (London, England) · 2019Article
- Perfusion magnetic resonance imaging in differentiation of neurocysticercosis and tuberculoma.Neuroradiology · 2019Article
- A model of chronic enthesitis and new bone formation characterized by multimodal imaging.Disease models & mechanisms · 2018Article
- The Micro-RNA Expression Profiles of Autoimmune Arthritis Reveal Novel Biomarkers of the Disease and Therapeutic Response.International journal of molecular sciences · 2018Article
- Effect of intravitreal injection of ranibizumab on retinal ganglion cells and microvessels in the early stage of diabetic retinopathy in rats with streptozotocin-induced diabetes.Experimental and therapeutic medicine · 2017Article
- Potentiation and tolerance of toll-like receptor priming in human endothelial cells.Translational research : the journal of laboratory and clinical medicine · 2017Article
- Regulation of blood flow and volume exchange across the microcirculation.Critical care (London, England) · 2016Review
- Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation.The Journal of clinical investigation · 2016Article
- Ninjurin1 inhibits colitis-mediated colon cancer development and growth by suppression of macrophage infiltration through repression of FAK signaling.Oncotarget · 2016Article
- Contribution of synovial lining cells to synovial vascularization of the rat temporomandibular joint.Journal of anatomy · 2016Article
- Targeted complement inhibition and microvasculature in transplants: a therapeutic perspective.Clinical and experimental immunology · 2016Review
- NG2 Proteoglycan-Dependent Contributions of Pericytes and Macrophages to Brain Tumor Vascularization and Progression.Microcirculation (New York, N.Y. : 1994) · 2016Review
- Anthrax Toxin Receptor 1 Is Essential for Arteriogenesis in a Mouse Model of Hindlimb Ischemia.PloS one · 2016Article
- Emerging trends in the pathophysiology of lymphatic contractile function.Seminars in cell & developmental biology · 2015Review
- Housing conditions modulate the severity of Mycoplasma pulmonis infection in mice deficient in class A scavenger receptor.Comparative medicine · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Angiogenesis and vascular remodeling are features of many chronic inflammatory diseases. When diseases evolve slowly, the accompanying changes in the microvasculature would seem to be similarly gradual. Here we report that the rate of endothelial cell proliferation and the size of blood vessels increases rapidly after the onset of an infection that leads to chronic inflammatory airway disease. In C3H mice inoculated with Mycoplasma pulmonis, the tracheal microvasculature, made visible by perfusion of Lycopersicon esculentum lectin, rapidly enlarged from 4 to 7 days after infection and then plateaued. Diameters of arterioles, capillaries, and venules increased on average 148, 214, and 74%, respectively. Endothelial cell proliferation, measured by bromodeoxyuridine (BrdU) labeling, peaked at 5 days (18 times the pathogen-free value), declined sharply until day 9, but remained at approximately 3 times the pathogen-free value for at least 28 days. Remodeled capillaries and venules were sites of focal plasma leakage and extensive leukocyte adherence. Most systemic manifestations of the infection occurred well after the peak of endothelial proliferation, and the humoral immune response to M. pulmonis was among the latest, increasing after 14 days. These data show that endothelial cell proliferation and microvascular remodeling occur at an early stage of chronic airway disease and suggest that the vascular changes precede widespread tissue remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.