ArticleJournal of muscle research and cell motility2000
Fibre types and myosin heavy chain expression in the ocular medial rectus muscle of the adult rat.
Article in Journal of muscle research and cell motility, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Extreme Tolerance of Extraocular Muscles to Diseases and Aging: Why and How?International journal of molecular sciences · 2024Review
- Complex tropomyosin and troponin T isoform expression patterns in orbital and global fibers of adult dog and rat extraocular muscles.Journal of muscle research and cell motility · 2013Article
- Development transitions of thin filament proteins in rat extraocular muscles.Experimental cell research · 2013Article
- A continuum of myofibers in adult rabbit extraocular muscle: force, shortening velocity, and patterns of myosin heavy chain colocalization.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Pitx2 regulates myosin heavy chain isoform expression and multi-innervation in extraocular muscle.The Journal of physiology · 2011Article
- Postnatal changes in the developing rat extraocular muscles.Investigative ophthalmology & visual science · 2011Article
- Myosin heavy chain expression in mouse extraocular muscle: more complex than expected.Investigative ophthalmology & visual science · 2010Article
- Sarcomeric myosin expression in the tongue body of humans, macaques and rats.Cells, tissues, organs · 2010Article
- Histochemical and immunohistochemical profile of human and rat ocular medial rectus muscles.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2009Article
- Palisade endings in extraocular eye muscles revealed by SNAP-25 immunoreactivity.Journal of anatomy · 2005Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myosin heavy chain (MHC) expression was determined immunohistochemically in individual muscle fibre types characterised by activities of ATPase and the key oxidative and glycolytic enzymes in rat ocular medial rectus (MR) muscles. In the global layer (GL), glycolytic activity of muscle fibres was higher and oxidative activity lower, than in the orbital layer (OL). Muscle fibres in the former displayed rosette-like organisation with a slow fibre surrounded by several fast fibres, which expressed either MHCIIa or MHCIIb, but many co-expressed both isoforms. In the OL some slow fibres co-expressed MHCIIa. Extraocular MHC isoform (MHCeom) could not be determined immunohistochemically and no pure MHCIIx/d containing fibres were found, suggesting that these isoforms, demonstrated electrophoretically, are co-expressed with others. Slow muscle fibres in both layers co-expressed MHCbeta slow, MHCalpha cardiac and MHC-slow tonic. Neonatal isoform (MHCneo) was co-expressed in several fast and slow muscle fibres in the orbital, but not global layer. Slow fibres in the GL displayed very low oxidative activity. Electrophoretic analysis of ocular MR muscle homogenates revealed that about 50% of total MHC was MHCIIb, MHCeom was quite prominent (25%), and MHCIIa, MHCIIx/d and MHCI contributed each about 8%. MHCneo, MHCslow tonic and MHCalpha cardiac could not be identified as separate bands.
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