ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Oxidative stress in cardiovascular disease.
Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 62 citations in OpenAlex.
- A Novel Mechanism for Atherosclerotic Calcification: Potential Resolution of the Oxidation Paradox.Antioxidants & redox signaling · 2018Article
- Global Metabolomics Reveals the Metabolic Dysfunction in Ox-LDL Induced Macrophage-Derived Foam Cells.Frontiers in pharmacology · 2017Article
- Tormentic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NF-κB signaling pathway.Molecular medicine reports · 2016Article
- Athletes with higher VOBMJ open sport & exercise medicine · 2015Article
- Estrogens as antioxidant modulators in human fertility.International journal of endocrinology · 2013Review
- Antimicrobial potential of selected brown seaweeds from Vedalai coastal waters, Gulf of Mannar.Asian Pacific journal of tropical biomedicine · 2011Article
- Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells.PPAR research · 2011Article
- Hormones and antioxidant systems: role of pituitary and pituitary-dependent axes.Journal of endocrinological investigation · 2010Review
- Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice.Atherosclerosis · 2010Article
- Lipid peroxidation and decomposition--conflicting roles in plaque vulnerability and stability.Biochimica et biophysica acta · 2008Review
- Effects of antioxidant-rich foods on vascular reactivity: review of the clinical evidence.Current atherosclerosis reports · 2006Review
- The postprandial effects of dietary antioxidants in humans.Current atherosclerosis reports · 2003Review
- Did the antioxidant trials fail to validate the oxidation hypothesis?Current atherosclerosis reports · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The oxidative hypothesis of cardiovascular disease (CVD) has undergone tremendous changes during the past few years. Innumerable new proatherogenic effects have been added to the existing list that could be attributed to oxidative stress. However, both animal and human trials with a variety of antioxidants have failed to establish unambiguously a protective role for antioxidants in the prevention of CVD. This could be because of poor choice and dosage of antioxidants, incompatible experimental models, oxidative metabolism of the antioxidant, unrealistic expectations, and other reasons. More importantly, recent studies suggest that oxidative stress also could induce antioxidant enzymes in both cell culture and in vivo systems. In lieu of the potential of known deterrents of CVD such as exercise, estrogens, and the consumption of polyunsaturated fatty acids to induce an oxidative stress, the possibility that natural enhancement of antioxidant defense in the artery could better serve to deter CVD cannot be ignored. Thus, if oxidative stress does play a role in CVD, it may be better, in the absence of suitable animal models that respond to antioxidants, to adhere to behavioral and dietary changes that have been shown to benefit CVD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.