ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Dipyridamole-induced increased glucose uptake in patients with single-vessel coronary artery disease assessed with PET.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 32 citations in OpenAlex.
- State-of-the-Art of Myocardial Perfusion by CMR: A Practical View.Reviews in cardiovascular medicine · 2022Review
- Value of combined perfusion and metabolic tracers versus stress-rest perfusion imaging for coronary heart disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Dual-time-point myocardialBMC cardiovascular disorders · 2017Article
- Effect of Dipyridamole Injected for Myocardial Perfusion Imaging on Blood Glucose Concentration; A Preliminary Study.Journal of clinical and diagnostic research : JCDR · 2016Article
- Comparison of Tc-99m tetrofosmin myocardial perfusion scintigraphy and exercise F18-FDG imaging in detection of myocardial ischemia in patients with coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Direct myocardial ischemia imaging: a new cardiovascular nuclear imaging paradigm.Clinical cardiology · 2015Review
- Direct myocardial ischemia imaging with exercise ¹⁸FDG.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Ischaemic memory imaging using metabolic radiopharmaceuticals: overview of clinical settings and ongoing investigations.European journal of nuclear medicine and molecular imaging · 2014Review
- Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing.International journal of vascular medicine · 2012Article
- Dipyridamole reverses peripheral ischemia and induces angiogenesis in the Db/Db diabetic mouse hind-limb model by decreasing oxidative stress.Free radical biology & medicine · 2011Article
- Exercise (18)FDG imaging for the detection of CAD: What are the clinical hurdles?Current cardiology reports · 2010Review
- Is BMIPP a sensitive marker for myocardial ischaemic stress? For.European journal of nuclear medicine and molecular imaging · 2004Article
- Myocardial glucose uptake after dobutamine stress in chronic hibernating swine myocardium.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- The Japanese experience with metabolic imaging in the clinical setting.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
- Direct imaging of myocardial ischemia: a potential new paradigm in nuclear cardiovascular imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Risk stratification of the normal perfusion scan: does normal stress perfusion always mean very low risk?Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
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5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to determine the relationship between vasodilatation-induced ischemia and poststress glucose uptake. Coronary vasodilators may induce myocardial ischemia due to coronary steal through collateral circulation or transmural blood flow redistribution with diminished subendocardial perfusion. Myocardial ischemia can be demonstrated by increased glucose uptake as previously shown in patients with exercise-induced ischemia. METHODS AND
resultsWe studied 11 patients with single-vessel disease and no history of myocardial infarction. Five patients had no collateral circulation, and 6 had angiographic evidence of collateral vessels. We measured myocardial blood flow (MBF) and glucose uptake at baseline and after the administration of dipyridamole (0.56 mg/kg) with positron emission tomography, using O-15 water and fluorine 18 deoxyglucose (FDG) as perfusion and glucose tracers. MBF at baseline was 0.82 +/- 0.13 mL/g/min in normal areas and 0.80 +/- 0.15 mL/g/min in areas supplied by stenotic arteries. MBF during dipyridamole was 2.05 +/- 0.66 and 1.19 +/- 0.66 mL/g/min in normal areas and areas with stenotic arteries, respectively (P < or = .001). FDG uptake at baseline was 1.36 +/- 0.55 in normal areas and 1.57 +/- 0.62 in areas supplied by stenotic arteries. FDG uptake after dipyridamole infusion was 1.79 +/- 1.1 and 4.04 +/- 0.84 in normal areas and areas with stenotic arteries, respectively (P < or =.001). MBF and FDG uptake were not different between patients with collateral circulation and those without collateral circulation.
conclusionsIncreased myocardial glucose uptake was consistently observed after dipyridamole administration in those areas with diminished coronary vasodilatory capacity. The similar MBF and FDG findings in patients with and without collateral circulation may indicate that transmural blood flow redistribution appears to be a possible mechanism of dipyridamole-induced myocardial ischemia.
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