ArticleProceedings of the National Academy of Sciences of the United States of America2001
Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Novel, Non-Gene-Destructive Knock-In Reporter Mice Refute the Concept of MonoallelicJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Correction of T cell deficiency in ZAP-70 knock-out mice by simple intraperitoneal adoptive transfer of thymocytes.Clinical and experimental immunology · 2018Article
- Identification of a novel lymphoid population in the murine epidermis.Scientific reports · 2015Article
- Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis.The Journal of experimental medicine · 2013Article
- Extrathymic development of murine T cells after bone marrow transplantation.The Journal of clinical investigation · 2012Article
- Signal integration and crosstalk during thymocyte migration and emigration.Nature reviews. Immunology · 2011Review
- Hematopoietic progenitor migration to the adult thymus.Annals of the New York Academy of Sciences · 2011Review
- T-cell lineage determination.Immunological reviews · 2010Review
- Article
- The long road to the thymus: the generation, mobilization, and circulation of T-cell progenitors in mouse and man.Seminars in immunopathology · 2008Review
- Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation.Blood · 2006Article
- Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors.The EMBO journal · 2005Article
- T lymphoid differentiation in human bone marrow.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We searched for clonable committed T cell progenitors in the adult mouse bone marrow and isolated rare (approximately 0.05%) cells with the Thy-1hiCD2-CD16+CD44hiCD25-Lin- phenotype. In vivo experiments showed that these cells were progenitors committed only to reconstituting the T cell lineage of irradiated Ly5 congenic hosts. Reconstitution of the thymus was minimal compared with that of the bone marrow, spleen, and lymph nodes. At limiting dilutions, donor T cell reconstitution of the spleen frequently occurred without detectable donor cells in the thymus. Progenitors were capable of rapidly reconstituting athymic hosts. In conclusion, the clonable bone marrow progenitors were capable of T cell reconstitution predominantly by means of an extrathymic pathway.
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