ArticleProceedings of the National Academy of Sciences of the United States of America2001
Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 56 citations in OpenAlex.
- Article
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- Acceleration of biomolecular kinetics in Gaussian accelerated molecular dynamics.The Journal of chemical physics · 2018Article
- Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics.Molecular biology of the cell · 2017Article
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- Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia.Science signaling · 2016Article
- Rethinking the role of immunoglobulin E and its high-affinity receptor: new insights into allergy and beyond.International archives of allergy and immunology · 2014Review
- T cell antigen recognition at the cell membrane.Molecular immunology · 2012Review
- Tunable kinetic proofreading in a model with molecular frustration.Theory in biosciences = Theorie in den Biowissenschaften · 2012Article
- Systems biology in immunology: a computational modeling perspective.Annual review of immunology · 2011Review
- The Influence of Look-Ahead on the Error Rate of Transcription.Mathematical modelling of natural phenomena · 2010Article
- Pairing computation with experimentation: a powerful coupling for understanding T cell signalling.Nature reviews. Immunology · 2010Review
- The SCHOOL of nature: I. Transmembrane signaling.Self/nonself · 2010Article
- Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation.Molecular systems biology · 2009Article
- Kinetic proofreading of ligand-FcepsilonRI interactions may persist beyond LAT phosphorylation.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Stochastic models of receptor oligomerization by bivalent ligand.Journal of the Royal Society, Interface · 2006Article
- Total internal reflection with fluorescence correlation spectroscopy: nonfluorescent competitors.Biophysical journal · 2004Article
- Ligand-receptor kinetics measured by total internal reflection with fluorescence correlation spectroscopy.Biophysical journal · 2003Article
- Signaling cascades: escape from kinetic proofreading.Proceedings of the National Academy of Sciences of the United States of America · 2001Review
- Unexpected signals in a system subject to kinetic proofreading.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
In the context of cell signaling, kinetic proofreading was introduced to explain how cells can discriminate among ligands based on a kinetic parameter, the ligand-receptor dissociation rate constant. In the kinetic proofreading model of cell signaling, responses occur only when a bound receptor undergoes a complete series of modifications. If the ligand dissociates prematurely, the receptor returns to its basal state and signaling is frustrated. We extend the model to deal with systems where aggregation of receptors is essential to signal transduction, and present a version of the model for systems where signaling depends on an extrinsic kinase. We also investigate the kinetics of signaling molecules, "messengers," that are generated by aggregated receptors but do not remain associated with the receptor complex. We show that the extended model predicts modes of signaling that exhibit kinetic discrimination for some range of parameters but for other parameter values show little or no discrimination and thus escape kinetic proofreading. We compare model predictions with experimental data.
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